TY - JOUR AU - Yong Din, Kim AU - Mikirtichev, K AU - Matkurbanov, O AU - Allamov, E AU - Kim, V AU - Sartabaev, B AU - Mukhtarov, K AU - Agababyan, L AU - Sakhhibbaev, M AU - Khusainov, R PY - 2020/04/30 Y2 - 2024/03/29 TI - Comparative evaluation of pre-infusion at caesar section performed under spinal anesthesia. Results of multicenter trial JF - Pain medicine JA - PMJUA VL - 5 IS - 1 SE - Original article DO - 10.31636/pmjua.v5i1.4 UR - https://painmedicine.org.ua/index.php/pnmdcn/article/view/217 SP - 37-42 AB - <p>Abstact. Study of the effect of preinfusion, various infusion solutions on the state of hemodynamics, in patients undergoing a cesarean section performed under spinal anesthesia with 0.5 % solution of Longocain Heavy (0.5 % hyperbaric bupivacaine).<br>Materials and methods. Spinal anesthesia (SAN) was performed in 2 190 women, aged 21 to 39 years, with a gestational age of 39 to 40 weeks. The structure of extragenital pathology was dominated by chronic anemia of varying severity – 1 650 (75.3 %), urinary tract infections – 756 (34.5 %), mild preeclampsia – 245 (11.2 %), chronic nonspecific lung diseases – 125 (5.7 %). 1 786 (81.5 %) patients underwent surgery in a planned manner, according to emergency indications – 404 (18.4 %). A combination of the two pathologies was observed in 852 (38.9 %) women. Indications for surgery were: disease of the operated uterus, insolvency of the scar on the uterus, clinically narrow pelvis, high-grade myopia, secondary labor weakness. The duration of surgery is ranged from 40 to 52 minutes.<br>Results. In group I, the expressed hypotension, requiring sympathomimetic support with mezaton was observed in 192 (34.8 %) patients. In group II, severe hypotension requiring sympathomimetic support with mezaton was observed in 114 (20.8 %) patients. And in group III, hypotension requiring sympathomimetic support with mezaton was observed in 127 (23.2 %) patients. At that time, in patients of group IV severe hypotension, requiring sympathomimetic support with mezaton was observed in only 91 (18 %) cases.<br>Conclusions. Neuraxial anesthesia is accompanied by the development of hypotension, which can be prevented by preinfusion with crystalloid solutions. Aggressive preinfusion of large volumes of isoosmolar crystalloids at a dose of 10–14 ml/kg was associated with an increase in the frequency of hemodynamic instability requiring sympathomimetic support.</p> ER -