Pain medicine 2019-09-02T13:11:32+03:00 Oleksandr Marchuk Open Journal Systems <p>"Medicina bolu" is a science-and-practice periodical for medical professionals. The main highlighting issue is pain, but not the only one, because in medicine there are no situations where a phenomenon is strictly isolated. Sign up for a print edition and follow up on the site to keep up with important and useful information.</p> <p>Thematic interests of the journal<br>Fundamental aspects of pain (clinical physiology, pathophysiology, pharmacology).<br>Applied aspects of pain (epidemiology, pain assessment, innovative methods of diagnosis and treatment, clinical pharmacology).<br>Clinical aspects of pain (acute pain, chronic pain, perioperative pain, posthumous pain, neuropathic pain, dysfunctional pain).<br>Clinical and anatomical approach to pain (headache, orofacial pain, neck and back pain, toothache, musculoskeletal pain, myofascial pain, fibromyalgia, visceral pain, pelvic pain, cardialgia, etc.).<br>Interdisciplinary approach to pain (in anesthesiology, in surgery, in pediatrics, neurology, vertebrology, in the clinic of internal diseases, oncology, rheumatology, gerontology, gastroenterology, traumatology and orthopedics, otorhinolaryngology, dentistry, obstetrics, gynecology and urology, in the palliative and hospice medicine).<br>Treatment and rehabilitation of patients suffering from pain (pharmacotherapy, physical rehabilitation, medical rehabilitation, alternative methods of treatment, means of psychological and psychotherapeutic influence, invasive methods of pain relief, organization of pain relief).<br>Separate clinical cases and their clinical examination.</p> Neuropathic pain: mechanisms of development, principles of diagnostics and treatment 2019-09-02T13:11:32+03:00 Dmytro Dmytriiev Pylyp Prudius Olesia Zaletskaya Yevhen Lisak Yurii Rudnitsky Nadiia Korenchuk <p>Neuropathic pain is a pain caused by a disease or focal damage to the somatosensory nervous system. The prevalence of chronic pain with neuropathic features in different countries is estimated at 7–10 %. Damages to the nervous system can occur at the level of peripheral nerves, plexus and dorsal roots (peripheral neuropathic pain) or spinal cord and brain (central neuropathic pain). Neuropathic pain is based on pathological activation of pain pathways. Neuropathic pain occurs with diabetic polyneuropathy more often than with all polyneuropathies of another etiology. Hyperglycemia is the major cause of chronic diabetes mellitus and its progression. Since the cause of pain can rarely be cured, treatment is usually symptomatic. Neuropathic pain is generally poorly controlled by analgesics. NB management is started with conservative pharmacotherapy before applying invasive analgesia. Although there are many drugs that can be used in patients with DPN, monotherapy can not always stop pain syndrome. In addition, the patient may not tolerate the full therapeutic dose of the drug. All this dictates the need for combination therapy.</p> 2019-07-15T00:00:00+03:00 Copyright (c) Anesthesia and sleep disorders – a new problem in modern anesthesiology (literature review) 2019-08-20T23:36:19+03:00 Oleksii Boduliev Dmytro Shkurupii <p>Sleep is an active state that is as complex as wakefulness. The main tasks of sleep are the adaptation and restoration of physical and mental strength.</p> <p>Sleep regulation is a complex multimodal process involving not only neurotransmitters, but also releasing­factors, hormones, cytokines, signaling molecules and metabolites.</p> <p>Having a lot of physiological effects, postoperative sleep plays a role not only in quality of life, but also in the recovery of the patient.</p> <p>The characteristics of the patient, the type of surgical intervention, the methods of anesthesia and their interaction affects postoperative sleep, but the relationship and the level of influence of these factors are not clear. Therefore, given the high prevalence of postoperative insomnia, this problem is relevant for modern anesthesiology.</p> 2019-07-16T00:00:00+03:00 Copyright (c) The Comparison of Neutropenia and Peripheral Neuropathy Condition as an Impact of 3-hours and 24-hour Paclitaxel Infusion of Paclitaxel-Carboplatin Chemotherapy on Ovarian Cancer Patients 2019-08-20T23:36:21+03:00 Primandono Perbowo Brahmana Askandar Ratna Soebady Ahcmad Bashory <p>This study is aimed to compare the difference of neutropenia with peripheral neuropathy condition, after administration of 3 hours and 24 hours Paclitaxel infusion in adjuvant therapy with Paclitaxel­Carboplatin toward patient with ovarian carcinoma. The method that used was experimental research with samples randomized after consecutively recruited based on inclusive criteria. Before and every after chemotherapy, NCS was performed and differential count laboratories’ test and then analysed with T­test and Chi­square test. The result showed that from three times administration of 3 hours Paclitaxel­Carboplatin infusion group, the neutropenia condition after first up to third chemotherapy was 20 %, 30 %, 30 %, and the peripheral neuropathy condition was 30 %, 60 %, 50 % respectively. Meanwhile, in 24 hours Paclitaxel­Carboplatin infusion group, the incident of neutropenia after first up to third chemotherapy was 40 %, 50 %, 40 %, and the incident of peripheral neuropathy was 20 %, 20 %, 20 % respectively. The statistic result was p &gt; 0.05. Hence, there was no significant difference in neutropenia and peripheral neuropathy incident on two study group.</p> 2019-07-15T00:00:00+03:00 Copyright (c) Menstrual Pain: A Review of Foreign Literature 2019-08-29T19:58:15+03:00 Kateryna Ostrovska <p>The World Health Organization estimates dysmenorrhea as the most important cause of a chronic pelvic pain. Its prevalence among adolescents and young women ranges from 40 % to 90 %, and varies, depending on age, country of residence and population density of the area. Primary dysmenorrhea is responsible for reducing the quality of life, absenteeism in the workplace or at school, refusing to participate in community and sporting events, changing of pain perception and sleep disturbance.</p> <p>There is evidence of its relationship with an early menarche, a family history, a length of the menstrual cycle, bad habits, poor sleep hygiene, an unbalanced diet, sedentary lifestyle and obesity. Characteristic features of a personality contribute in a certain way, making women prone to neuroticism and pain catastrophizing to be more at risk of developing dysmenorrhea.</p> <p>Irritable bowel syndrome, musculoskeletal pain and interstitial cystitis often accompany dysmenorrhea and respond to its treatment positively. Despite the proven validity of nonsteroidal anti­inflammatory drugs treatment there are resistant forms of menstrual pain, those make a search for alternative therapy relevant.</p> 2019-07-18T00:00:00+03:00 Copyright (c) Acute pelvic pain in young women. A modern look at the problem 2019-08-20T23:36:14+03:00 Viktor Konoplitskyi Yurii Korobko <p>The article is devoted to the main causes for the formation of pelvic pain syndrome in women, some etiological factors of the mechanism of its formation are depicted. A special analysis is devoted to the importance of differentiating surgical and gynecological pathologies in the formation of pelvic pain syndrome in women of different ages. The importance of appendicular­genital syndrome in maintaining the reproductive health of the younger generation is determined. A pathogenetically substantiated step­by­step algorithm of diagnostic and therapeutic measures based on a multidisciplinary approach to pathology is proposed.</p> 2019-07-19T00:00:00+03:00 Copyright (c)