A contemporary approach to sedation during regional anaesthesia in gynaecology


  • Yevhenii Grizhimalsky Maternity hospital “Leleka”, Kyiv, Ukraine
  • Andrii Harha Maternity hospital “Leleka”, Kyiv, Ukraine




sedation, regional anesthesia, dexmedetomidine


Safe and adequate sedation during regional anesthesia is one of the issues at the current time. According to the basic principles of modern anesthesiology, safe and effective sedation should protect the patient’s psycho-emotional sphere, provide absence of awareness, pain and fear during surgery as well as nausea and vomiting in the postoperative period. At the same time, it should neither cause respiratory depression and haemodynamics changes, nor be accompanied by a slow recovery of psychomotor function.
After studying modern literature and analyzing our own observations, we reached the point that sedation with dexmedetomidine rather than propofol is more preferred during regional anaesthesia. Sedation with dexmedetomidine decreases frequency of cognitive impairment in the early postoperative period, intensity of the pain syndrome, and has beneficial effect on recovery and activation after surgery. Additionally, it is associated with lower risk of hypoxemia and arterial hypotension during surgery.


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Svetlov VA, Zaytsev AYu, Kozlov SP.Balanced anesthesia based on regional blockades: strategy and tactics [Sbalansirovannaya anesteziya na osnove regionarnykh blokad: strategiya i taktika]. Anesteziologiya i reanimatologiya. 2006;4:4-33. [In Russian]

Precedex (dexmedetomidine). Hospira, Inc., Lake Forest, IL 60045 USA. Available from: http://medlibrary.org/lib/rx/meds/precedex/page/1-7/

Candiotti KA, Bergese SD, Bokesch PM, Feldman MA, Wisemandle W, Bekker AY. Monitored Anesthesia Care with Dexmedetomidine: A Prospective, Randomized, Double-Blind, Multicenter Trial. Anesthesia & Analgesia [Internet]. Ovid Technologies (Wolters Kluwer Health); 2010 Jan;110(1):47–56. Available from: https://doi.org/10.1213/ane.0b013e3181ae0856 DOI: https://doi.org/10.1213/ane.0b013e3181ae0856

Bergese SD, Candiotti KA, Bokesch PM, Zura A, Wisemandle W, Bekker AY. A Phase IIIb, Randomized, Double-blind, Placebo-controlled, Multicenter Study Evaluating the Safety and Efficacy of Dexmedetomidine for Sedation During Awake Fiberoptic Intubation. American Journal of Therapeutics [Internet]. Ovid Technologies (Wolters Kluwer Health); 2010 Nov;17(6):586–95. Available from: https://doi.org/10.1097/mjt.0b013e3181d69072 DOI: https://doi.org/10.1097/MJT.0b013e3181d69072

Wu W, Chen Q, Zhang L, Chen W. Dexmedetomidine versus midazolam for sedation in upper gastrointestinal endoscopy. Journal of International Medical Research [Internet]. SAGE Publications; 2014 Feb 10;42(2):516–22. Available from: https://doi.org/10.1177/0300060513515437 DOI: https://doi.org/10.1177/0300060513515437

Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The Effects of Increasing Plasma Concentrations of Dexmedetomidine in Humans. Anesthesiology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2000 Aug;93(2):382–94. Available from: https://doi.org/10.1097/00000542-200008000-00016 DOI: https://doi.org/10.1097/00000542-200008000-00016

Krasenkova EA, Ovechkin AY, Pyregov AV. Influence of anesthetic techniques on occurrence of postoperative cognitive dysfunction in elderly patients undergoing gynecological surgery. Bulletin of Russian State Medical University [Internet]. Pirogov Russian National Research Medical University; 2016;(4):51–5. Available from: https://doi.org/10.24075/brsmu.2016-04-08 DOI: https://doi.org/10.24075/brsmu.2016-04-08

Karelov АE, Lebedinskiy KM, Buravtsov VI. Anesthetic, analgetic, hypnotic – are the definitions important?. Anesteziologii I Reanimatologii, 2015;12(5):3-11. [In Russian]

Kulikov АS, Lubnin АYu. Dexmedetomidine: new opportunities in the anesthesiology. Anesteziologiya i Reanimatologiya. 2013;(1):37-41. [In Russian]

Сучасний підхід до седації під час реґіонарної анестезії в гінекології



How to Cite

Grizhimalsky Y, Harha A. A contemporary approach to sedation during regional anaesthesia in gynaecology. PMJUA [Internet]. 2020 Apr. 30 [cited 2023 Feb. 8];5(1):52-6. Available from: https://painmedicine.org.ua/index.php/pnmdcn/article/view/219



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