Effect of a single dose of preoperative gabapentin in oncourology on the intensity of early postoperative pain

Authors

  • I I Lisnyy SI “National Cancer Institute”, Anesthesiology and Intensive Care Department, Kyiv
  • L V Klimchuk SI “National Cancer Institute”, Anesthesiology and Intensive Care Department, Kyiv

DOI:

https://doi.org/10.31636/pmjua.v5i4.3

Keywords:

pain, gabapentine, premedication

Abstract

Objective: to evaluate the intensity of early postoperative pain after a single preoperative administration of gabapentin during surgical interventions in oncourology.

Materials and methods: patients were randomized into two groups of 25 people each: group 1 (Gr. 1) received gabapentin at a dose of 300 mg for premedication at night, and group 2 (Gr. 2), in which patients did not receive gabapentin. The need for propofol during anesthesia, the need for fentanyl during anesthesia, and the intensity of pain at 2, 4, 6, 12 and 24 hours after surgery were assessed on the VAS scale at rest and during movement.

Results of the study: it was shown that in patients who received gabapentin at a dose of 300 mg for premedication, the need for propofol and fentanyl was significantly lower when compared with patients who did not receive gabapentin, p = 0.0001. The intensity of postoperative pain syndrome in patients in Gr. 1 was significantly lower only when assessed at rest, while no statistically significant differences were found in the quality of pain relief during movement.

Conclusions: the use of gabapentin at a dose of 300 mg for premedication significantly reduces the intensity of postoperative pain at rest, but not during movement, and also reduces the need for propofol and fentanyl during surgery.

Downloads

Download data is not yet available.

References

Feng Y, Cui M, Willis WD. Gabapentin Markedly Reduces Acetic Acid–induced Visceral Nociception. Anesthesiology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2003 Mar 1;98(3):729–33. Available from: https://doi.org/10.1097/00000542-200303000-00023

Mao J, Chen LL. Gabapentin in Pain Management. Anesthesia & Analgesia [Internet]. Ovid Technologies (Wolters Kluwer Health); 2000 Sep;680–7. Available from: https://doi.org/10.1097/00000539-200009000-00034

Ho K-Y, Gan TJ, Habib AS. Gabapentin and postoperative pain – a systematic review of randomized controlled trials. Pain [Internet]. Ovid Technologies (Wolters Kluwer Health); 2006 Dec;126(1):91–101. Available from: https://doi.org/10.1016/j.pain.2006.06.018

Tiippana EM, Hamunen K, Kontinen VK, Kalso E. Do Surgical Patients Benefit from Perioperative Gabapentin/Pregabalin? A Systematic Review of Efficacy and Safety. Anesthesia & Analgesia [Internet]. Ovid Technologies (Wolters Kluwer Health); 2007 Jun;104(6):1545–56. Available from: https://doi.org/10.1213/01.ane.0000261517.27532.80

Kehlet H. Postoperative Opioid Sparing to Hasten Recovery. Anesthesiology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2005 Jun 1;102(6):1083–5. Available from: https://doi.org/10.1097/00000542-200506000-00004

Kehlet H, Dahl JB. The Value of ”Multimodal” or ”Balanced Analgesia” in Postoperative Pain Treatment. Anesthesia & Analgesia [Internet]. Ovid Technologies (Wolters Kluwer Health); 1993 Nov;77(5):1048-1056. Available from: https://doi.org/10.1213/00000539-199311000-00030

Gilron I, Bailey J, Tu D, Holden R, Weaver D, Houlden R. Randomized controlled trial of a morphine-gabapentin combination in neuropathic pain. The Journal of Pain [Internet]. Elsevier BV; 2005 Mar;6(3):S41. Available from: https://doi.org/10.1016/j.jpain.2005.01.162

Rorarius MG., Mennander S, Suominen P, Rintala S, Puura A, Pirhonen R, et al. Gabapentin for the prevention of postoperative pain after vaginal hysterectomy. Pain [Internet]. Ovid Technologies (Wolters Kluwer Health); 2004 Jul;110(1):175–81. Available from: https://doi.org/10.1016/j.pain.2004.03.023

Al-Mujadi H, A-Refai AR, Katzarov MG, Dehrab NA, Batra YK, Al-Qattan AR. Preemptive gabapentin reduces postoperative pain and opioid demand following thyroid surgery. Canadian Journal of Anesthesia [Internet]. Springer Science and Business Media LLC; 2006 Mar;53(3):268–73. Available from: https://doi.org/10.1007/bf03022214

Turan A, Kaya G, Karamanlioğlu B, Pamukçu Z, Apfel CC. Effect of oral gabapentin on postoperative epidural analgesia †. British Journal of Anaesthesia [Internet]. Elsevier BV; 2006 Feb;96(2):242–6. Available from: https://doi.org/10.1093/bja/aei294

Dirks J, Petersen KL, Rowbotham MC, Dahl JB. Gabapentin Suppresses Cutaneous Hyperalgesia following Heat-Capsaicin Sensitization. Anesthesiology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2002 Jul 1;97(1):102–7. Available from: https://doi.org/10.1097/00000542-200207000-00015

Hurley RW, Chatterjea D, Rose Feng M, Taylor CP, Hammond DL. Gabapentin and Pregabalin Can Interact Synergistically with Naproxen to Produce Antihyperalgesia. Anesthesiology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2002 Nov 1;97(5):1263–73. Available from: https://doi.org/10.1097/00000542-200211000-00033

Turan A, Karamanlıoğlu B, Memiş D, Hamamcıoglu MK, Tükenmez B, Pamukçu Z, et al. Analgesic Effects of Gabapentin after Spinal Surgery. Anesthesiology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2004 Apr 1;100(4):935–8. Available from: https://doi.org/10.1097/00000542-200404000-00025

Pandey CK, Singhal V, Kumar M, Lakra A, Ranjan R, Pal R, et al. Gabapentin provides effective postoperative analgesia whether administered pre-emptively or post-incision. Canadian Journal of Anesthesia/Journal canadien d’anesthésie [Internet]. Springer Science and Business Media LLC; 2005 Oct;52(8):827–31. Available from: https://doi.org/10.1007/bf03021777

Yoon MH, Yaksh TL. The Effect of Intrathecal Gabapentin on Pain Behavior and Hemodynamics on the Formalin Test in the Rat. Anesthesia & Analgesia [Internet]. Ovid Technologies (Wolters Kluwer Health); 1999 Aug;89(2):434–9. Available from: https://doi.org/10.1097/00000539-199908000-00034

Влияние однократного применения габапентина перед хирургическим вмешательством в онкоурологии на интенсивность ранней послеоперационной боли

Downloads

Published

2021-03-11

How to Cite

1.
Lisnyy II, Klimchuk LV. Effect of a single dose of preoperative gabapentin in oncourology on the intensity of early postoperative pain. PMJUA [Internet]. 2021 Mar. 11 [cited 2021 Jun. 21];5(4):16-21. Available from: https://painmedicine.org.ua/index.php/pnmdcn/article/view/238

Issue

Section

Original article