Theories of pain, up to Descartes and after neuromatrix: what role do they have to develop future paradigms?

  • I. Burmistr Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova
Keywords: history of medicine, pain theories, neuromatrix, human microbiota


The article represents a synthesis of literature about antique, medieval and modern pain theories. In short there are described the most relevant theories about nociception and pain. Chronologically there are presented the discoveries in physiology, anatomy, histology and other methods and investigations of pain. There is discussed the character of past pain theories and its influence on elaboration of the new ones. There was elaborated the hypothesis about the neuromatrix theory and impact of human microbiota on pain perception or other comorbidities with psychological and pain component.


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How to Cite
Burmistr I. Theories of pain, up to Descartes and after neuromatrix: what role do they have to develop future paradigms?. PMJUA [Internet]. 7Mar.2018 [cited 21Mar.2019];3(1):6-2. Available from:
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