Itching as the onset of pain (part 2)
DOI:
https://doi.org/10.31636/pmjua.v5i1.3Keywords:
pain, itching, comorbidity, quality of lifeAbstract
Itching of the skin is a particularly unpleasant subjective sensation that causes the need to scratch. Physiological itching occurs in response to environmental irritants (friction, insect crawling, temperature changes, etc.) and disappears after elimination of the cause. Pathological itching is caused by changes in the skin or throughout the body and causes a strong need to get rid of itching by combing or any other method. Itching is a common symptom of local (dermatological) or general (systemic) disease. It can be limited (localized) or diffuse (generalized).
One of the causes of itching is often noted endocrine diseases and metabolic disorders: hyper- and hypofunction of the thyroid gland, diabetes mellitus and hyperparathyroidism. In thyroid hyperfunction, generalized (inconstant and little-pronounced) itching of the skin is observed in the clinical picture only in 10 % of patients. It is accepted that itching of the skin in thyrotoxicosis syndrome is due to increased activity of kinin in combination with an increase in major metabolism and an increase in body and skin temperature (123).
Itching caused by impaired bile secretion is characteristic of many diseases of the liver: primary biliary cirrhosis, sclerosing cholangitis, viral hepatitis caused by cholestasis medications and other causes of obstructive jaundice. It is in these cases that prurigo is usually generalized, but in some typical cases it is more pronounced on the feet and palms. With this pathology, itching is caused by obstruction of the biliary tract, however, and to this day, no close correlation has been found between serum bilirubin and the severity of itching.
If it was previously thought that itching in pathology of the peripheral or central nervous system, such as multiple sclerosis, neuropathy, compression or irritation of nerves (e.g., paraesthetic dorsalgia, brachioradial itching) is also a significant symptom, then modern studies prove that in more cases, itching is not characteristic of most pathologies of the nervous system, so after a detailed anamnesis, examination and initial research, the patient should be referred to a related specialist, except in cases of about obvious postherpetic neuropathy, painless paresthesia, or brachioradial itching, which can often be guided in the provision of primary care.
Instead, there are some psychological conditions and a number of psychiatric illnesses (obsessive-compulsive disorders, depression, and parasite illusions) that are most commonly diagnosed with the exclusion method. Neurotic squabbles are scattered on the body of the excorii, covered with scales that may occur in any area of the body that the patient may reach, but are often limited by limbs.
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References
Sato S. Iron deficiency: structural and microchemical changes in hair, nails, and skin. InSeminars in dermatology. 1991 Dec;10(4):313-319.
Cassano N, Tessari G, Vena GA, Girolomoni G. Chronic Pruritus in the Absence of Specific Skin Disease. American Journal of Clinical Dermatology [Internet]. Springer Science and Business Media LLC; 2010 Dec;11(6):399–411. Available from: https://doi.org/10.2165/11317620-000000000-00000 DOI: https://doi.org/10.2165/11317620-000000000-00000
Greaves MW. Pruritus. In: Rook's Textbook of Dermatology ( A Burns, S Breathnach, N Cox, C Griffiths, eds), 8th edn. Oxford: Blackwell Publishing, 2010;Chapter 21.
Artantaş Ş, Gül Ü, Kılıç A, Güler S. Skin findings in thyroid diseases. European journal of internal medicine. 2009 Mar 1;20(2):158-61. DOI: https://doi.org/10.1016/j.ejim.2007.09.021
Sommer F, Hensen P, Böckenholt B, Metze D, Luger T, Ständer S. Underlying Diseases and Co-factors in Patients with Severe Chronic Pruritus: a 3-year Retrospective Study. Acta Dermato-Venereologica [Internet]. Acta Dermato-Venereologica; 2007;87(6):510–6. Available from: https://doi.org/10.2340/00015555-0320 DOI: https://doi.org/10.2340/00015555-0320
Jabbour SA. Cutaneous manifestations of endocrine disorders. American journal of clinical dermatology. 2003 May 1;4(5):315-31. DOI: https://doi.org/10.2165/00128071-200304050-00003
Hampers CL, Katz AI, Wilson RE, Merrill JP. Disappearance of Uremic Itching after Subtotal Parathyroidectomy. New England Journal of Medicine [Internet]. Massachusetts Medical Society; 1968 Sep 26;279(13):695–7. Available from: https://doi.org/10.1056/nejm196809262791307 DOI: https://doi.org/10.1056/NEJM196809262791307
Massry SG, Popovtzer MM, Coburn JW, Makoff DL, Maxwell MH, Kleeman CR. Intractable Pruritus as a Manifestation of Secondary Hyperparathyroidism in Uremia. New England Journal of Medicine [Internet]. Massachusetts Medical Society; 1968 Sep 26;279(13):697–700. Available from: https://doi.org/10.1056/nejm196809262791308 DOI: https://doi.org/10.1056/NEJM196809262791308
Chou FF, Ho JC, Huang SC, Sheen-Chen SM. A study on pruritus after parathyroidectomy for secondary hyperparathyroidism. Journal of the American College of Surgeons. 2000 Jan 1;190(1):65-70. DOI: https://doi.org/10.1016/S1072-7515(99)00212-4
Shirazian S, Kline M, Sakhiya V, Schanler M, Moledina D, Patel C, et al. Longitudinal Predictors of Uremic Pruritus. Journal of Renal Nutrition [Internet]. Elsevier BV; 2013 Nov;23(6):428–31. Available from: https://doi.org/10.1053/j.jrn.2013.08.002 DOI: https://doi.org/10.1053/j.jrn.2013.08.002
El-Shafey EM, Alsahow AE, Alsaran K, Sabry AA, Atia M. Cinacalcet Hydrochloride Therapy for Secondary Hyperparathyroidism in Hemodialysis Patients. Therapeutic Apheresis and Dialysis [Internet]. Wiley; 2011 Nov 23;15(6):547–55. Available from: https://doi.org/10.1111/j.1744-9987.2011.00994.x DOI: https://doi.org/10.1111/j.1744-9987.2011.00994.x
Wu H-Y, Peng Y-S, Chen H-Y, Tsai W-C, Yang J-Y, Hsu S-P, et al. A Comparison of Uremic Pruritus in Patients Receiving Peritoneal Dialysis and Hemodialysis. Medicine [Internet]. Ovid Technologies (Wolters Kluwer Health); 2016 Mar;95(9):e2935. Available from: https://doi.org/10.1097/md.0000000000002935 DOI: https://doi.org/10.1097/MD.0000000000002935
Gatmiri SM, Mahdavi-Mazdeh M, Lessan-Pezeshki M, Abbasi M. Uremic pruritus and serum phosphorus level. Acta Medica Iranica. 2013:477-81.
Goetz DW. Idiopathic itch, rash, and urticaria/angioedema merit serum vitamin D evaluation: a descriptive case series. West Virginia Medical Journal. 2011 Jan 1;107(1):14-21.
King NK, Siriwardana HP, Coyne JD, Siriwardena AK. Intractable pruritus associated with insulinoma in the absence of multiple endocrine neoplasia: a novel paraneoplastic phenomenon. Scandinavian journal of gastroenterology. 2003 Jun;38(6):678-80. DOI: https://doi.org/10.1080/00365520310001950
Yamaoka H, Sasaki H, Yamasaki H, Ogawa K, Ohta T, Furuta H, et al. Truncal Pruritus of Unknown Origin May Be a Symptom of Diabetic Polyneuropathy. Diabetes Care [Internet]. American Diabetes Association; 2009 Dec 29;33(1):150–5. Available from: https://doi.org/10.2337/dc09-0632 DOI: https://doi.org/10.2337/dc09-0632
Dupuy P, Szepietowski J, Balaskas E, Taube K, Taberly A. Quality of Life in Patients with Uraemic Xerosis and Pruritus. Acta Dermato Venereologica [Internet]. Acta Dermato-Venereologica; 2011;91(3):313–7. Available from: https://doi.org/10.2340/00015555-1075 DOI: https://doi.org/10.2340/00015555-1075
Pisoni RL, Wikstrom B, Elder SJ, Akizawa T, Asano Y, Keen ML, et al. Pruritus in haemodialysis patients: international results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrology Dialysis Transplantation [Internet]. Oxford University Press (OUP); 2006 Sep 23;21(12):3495–505. Available from: https://doi.org/10.1093/ndt/gfl461 DOI: https://doi.org/10.1093/ndt/gfl461
Patel TS, Freedman BI, Yosipovitch G. An Update on Pruritus Associated With CKD. American Journal of Kidney Diseases [Internet]. Elsevier BV; 2007 Jul;50(1):11–20. Available from: https://doi.org/10.1053/j.ajkd.2007.03.010 DOI: https://doi.org/10.1053/j.ajkd.2007.03.010
Masmoudi A, Hajjaji Darouiche M, Ben Salah H, Ben Hmida M, Turki H. Cutaneous abnormalities in patients with end stage renal failure on chronic hemodialysis. A study of 458 patients. Journal of Dermatological Case Reports [Internet]. Specjalisci Dermatolodzy; 2014 Dec 31;8(4). Available from: https://doi.org/10.3315/jdcr.2014.1182 DOI: https://doi.org/10.3315/jdcr.2014.1182
Sayadi M, Pakfetrat M, Sepaskhah M, Roozbeh J, Malekmakan L, Malekmakan A. Association of high-sensitive C-reactive protein and dialysis adequacy with uremic pruritus. Saudi Journal of Kidney Diseases and Transplantation [Internet]. Medknow; 2015;26(5):890. Available from: https://doi.org/10.4103/1319-2442.164565 DOI: https://doi.org/10.4103/1319-2442.164565
Yosipovitch G, Reis J, Tur E, Sprecher E, Yarnitsky D, Boner G. Sweat secretion, stratum corneum hydration, small nerve function and pruritus in patients with advanced chronic renal failure. British Journal of Dermatology [Internet]. Wiley; 1995 Oct;133(4):561–4. Available from: https://doi.org/10.1111/j.1365-2133.1995.tb02705.x DOI: https://doi.org/10.1111/j.1365-2133.1995.tb02705.x
Ståhle‐Bäckdahl M. Uremic pruritus. Semin Dermatol. 1995;14:297–301. DOI: https://doi.org/10.1016/S1085-5629(05)80051-3
Zucker I, Yosipovitch G, David M, Gafter U, Boner G. Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease. Journal of the American Academy of Dermatology [Internet]. Elsevier BV; 2003 Nov;49(5):842–6. Available from: https://doi.org/10.1016/s0190-9622(03)02478-2 DOI: https://doi.org/10.1016/S0190-9622(03)02478-2
Karadag E, Kilic SP, Karatay G, Metin O. Effect of baby oil on pruritus, sleep quality, and quality of life in hemodialysis patients: Pretest-post-test model with control groups. Japan Journal of Nursing Science [Internet]. Wiley; 2013 Jun 20;11(3):180–9. Available from: https://doi.org/10.1111/jjns.12019 DOI: https://doi.org/10.1111/jjns.12019
Marchi SD, Cecchin E, Villalta D, Sepiacci G, Santini G, Bartoli E. Relief of Pruritus and Decreases in Plasma Histamine Concentrations during Erythropoietin Therapy in Patients with Uremia. New England Journal of Medicine [Internet]. Massachusetts Medical Society; 1992 Apr 9;326(15):969–74. Available from: https://doi.org/10.1056/nejm199204093261501 DOI: https://doi.org/10.1056/NEJM199204093261501
Hiroshige K, Kabashima N, Takasugi M, Kuroiwa A. Optimal dialysis improves uremic pruritus. American Journal of Kidney Diseases [Internet]. Elsevier BV; 1995 Mar;25(3):413–9. Available from: https://doi.org/10.1016/0272-6386(95)90102-7 DOI: https://doi.org/10.1016/0272-6386(95)90102-7
Ko M-J, Wu H-Y, Chen H-Y, Chiu Y-L, Hsu S-P, Pai M-F, et al. Uremic Pruritus, Dialysis Adequacy, and Metabolic Profiles in Hemodialysis Patients: A Prospective 5-Year Cohort Study. Moysés RMA, editor. PLoS ONE [Internet]. Public Library of Science (PLoS); 2013 Aug 6;8(8):e71404. Available from: https://doi.org/10.1371/journal.pone.0071404 DOI: https://doi.org/10.1371/journal.pone.0071404
Jiang X, Ji F, Chen Z-W, Huang Q-L. Comparison of high-flux hemodialysis with hemodialysis filtration in treatment of uraemic pruritus: a randomized controlled trial. International Urology and Nephrology [Internet]. Springer Science and Business Media LLC; 2016 Jul 5;48(9):1533–41. Available from: https://doi.org/10.1007/s11255-016-1364-2 DOI: https://doi.org/10.1007/s11255-016-1364-2
Tarng D-C, Cho Y-L, Liu H-N, Huang T-P. Hemodialysis-Related Pruritus: A Double-Blind, Placebo-Controlled, Crossover Study of Capsaicin 0.025% Cream. Nephron [Internet]. S. Karger AG; 1996;72(4):617–22. Available from: https://doi.org/10.1159/000188949 DOI: https://doi.org/10.1159/000188949
Makhlough A, ALA S, HAJHEYDARI Z, Kashi Z, BARI A. Topical capsaicin therapy for uremic pruritus in patients on hemodialysis. 2010;4:137–40.
Breneman DL, Cardone JS, Blumsack RF, Lather RM, Searle EA, Pollack VE. Topical capsaicin for treatment of hemodialysis-related pruritus. Journal of the American Academy of Dermatology. 1992 Jan 1;26(1):91-4. DOI: https://doi.org/10.1016/0190-9622(92)70013-6
Pauli-Magnus C, Mikus G, Alscher DM, Kirschner T, Nagel W, Gugeler N, Risler T, Berger ED, Kuhlmann U, Mettang T. Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study. Journal of the American Society of Nephrology. 2000 Mar 1;11(3):514-9.
Kuypers DR, Claes K, Evenepoel P, Maes B, Vanrenterghem Y. A prospective proof of concept study of the efficacy of tacrolimus ointment on uraemic pruritus (UP) in patients on chronic dialysis therapy. Nephrology Dialysis Transplantation [Internet]. Oxford University Press (OUP); 2004 May 18;19(7):1895–901. Available from: https://doi.org/10.1093/ndt/gfh202 DOI: https://doi.org/10.1093/ndt/gfh202
Ghorbani AR, Feily A, Khalili A, Dormanesh B. Lack of Efficacy of Topical Calcineurin Inhibitor Pimecrolimus 1% on Pruritus of Severely Uremic Patients: A Randomized Double-Blind Study in 60 Patients. Dermatitis [Internet]. Ovid Technologies (Wolters Kluwer Health); 2011 May;22(3):167–8. Available from: https://doi.org/10.2310/6620.2011.10110 DOI: https://doi.org/10.2310/6620.2011.10110
Duque MI, Yosipovitch G, Fleischer AB, Willard J, Freedman BI. Lack of efficacy of tacrolimus ointment 0.1% for treatment of hemodialysis-related pruritus: A randomized, double-blind, vehicle-controlled study. Journal of the American Academy of Dermatology [Internet]. Elsevier BV; 2005 Mar;52(3):519–21. Available from: https://doi.org/10.1016/j.jaad.2004.08.050 DOI: https://doi.org/10.1016/j.jaad.2004.08.050
Jung KE, Woo YR, Lee JS, Shin JH, Jeong JU, Koo DW, et al. Effect of topical vitamin D on chronic kidney disease-associated pruritus: An open-label pilot study. The Journal of Dermatology [Internet]. Wiley; 2015 Apr 28;42(8):800–3. Available from: https://doi.org/10.1111/1346-8138.12895 DOI: https://doi.org/10.1111/1346-8138.12895
Feily A, Dormanesh B, Ghorbani AR, Moosavi Z, Kouchak M, Cheraghian B, et al. Efficacy of topical cromolyn sodium 4% on pruritus in uremic nephrogenic patients: A randomized double-blind study in 60 patients. Int Journal of Clinical Pharmacology and Therapeutics [Internet]. Dustri-Verlgag Dr. Karl Feistle; 2012 Jul 1;50(07):510–3. Available from: https://doi.org/10.5414/cp201629 DOI: https://doi.org/10.5414/CP201629
Chen Y-C, Chiu W-T, Wu M-S. Therapeutic Effect of Topical Gamma-Linolenic Acid on Refractory Uremic Pruritus. American Journal of Kidney Diseases [Internet]. Elsevier BV; 2006 Jul;48(1):69–76. Available from: https://doi.org/10.1053/j.ajkd.2006.03.082 DOI: https://doi.org/10.1053/j.ajkd.2006.03.082
Francos GC, Kauh YC, Gittlen SD, Schulman ES, Besarab A, Goyal S, et al. Elevated Plasma Histamine in Chronic Uremia Effects of Ketotifen on Pruritus. International Journal of Dermatology [Internet]. Wiley; 1991 Dec;30(12):884–9. Available from: https://doi.org/10.1111/j.1365-4362.1991.tb04360.x DOI: https://doi.org/10.1111/j.1365-4362.1991.tb04360.x
Pourreza GF, Nasr EA, Firouzan A, Nasli EE, Farokhi F. Low-dose doxepin for treatment of pruritus in patients on hemodialysis. 2007;1:34–7.
Gray SL, Anderson ML, Dublin S, Hanlon JT, Hubbard R, Walker R, et al. Cumulative Use of Strong Anticholinergics and Incident Dementia. JAMA Internal Medicine [Internet]. American Medical Association (AMA); 2015 Mar 1;175(3):401. Available from: https://doi.org/10.1001/jamainternmed.2014.7663 DOI: https://doi.org/10.1001/jamainternmed.2014.7663
Weisshaar E, Dunker N, Rohl F-W, Gollnick H. Antipruritic effects of two different 5-HT3 receptor antagonists and an antihistamine in haemodialysis patients. Experimental Dermatology [Internet]. Wiley; 2004 May;13(5):298–304. Available from: https://doi.org/10.1111/j.0906-6705.2004.00184.x DOI: https://doi.org/10.1111/j.0906-6705.2004.00184.x
Naini AE, Harandi AA, Khanbabapour S, Shahidi S, Seirafiyan S, Mohseni M. Gabapentin: a promising drug for the treatment of uremic pruritus. Saudi Journal of Kidney Diseases and Transplantation. 2007 Jul 1;18(3):378-81.
Gunal AI, Ozalp G, Yoldas TK, Gunal SY, Kirciman E, Celiker H. Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. Nephrology Dialysis Transplantation [Internet]. Oxford University Press (OUP); 2004 Dec 1;19(12):3137–9. Available from: https://doi.org/10.1093/ndt/gfh496 DOI: https://doi.org/10.1093/ndt/gfh496
Tol H, Atalay H, Güney I . The Effects of Gabapentin Therapy on Pruritus, 4uality of Life, Depression and Sleep 4uality in Pruritic Hemodialysis Patients. Trakya Univ Tip Fak Derg. 2010;27(1):1–5.
Razeghi E, Eskandari D, Ganji MR, Meysamie AP, Togha M, Khashayar P. Gabapentin and Uremic Pruritus in Hemodialysis Patients. Renal Failure [Internet]. Informa UK Limited; 2009 Jan;31(2):85–90. Available from: https://doi.org/10.1080/08860220802595476 DOI: https://doi.org/10.1080/08860220802595476
Amirkhanlou S, Rashedi A, Taherian J, Hafezi AA, Parsaei S. Comparison of Gabapentin and Ketotifen in Treatment of Uremic Pruritus in Hemodialysis Patients. Pakistan Journal of Medical Sciences [Internet]. Pakistan Journal of Medical Sciences; 1969 Dec 31;32(1). Available from: https://doi.org/10.12669/pjms.321.8547 DOI: https://doi.org/10.12669/pjms.321.8547
Yue J, Jiao S, Xiao Y, Ren W, Zhao T, Meng J. Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a prospective, randomized, double-blind study. International Urology and Nephrology [Internet]. Springer Science and Business Media LLC; 2014 Aug 7;47(1):161–7. Available from: https://doi.org/10.1007/s11255-014-0795-x DOI: https://doi.org/10.1007/s11255-014-0795-x
Andrews PA, Quan V, Ogg CS. Ondansetron for symptomatic relief in terminal uraemia. Nephrology Dialysis Transplantation. 1995;10(1):140.
Albares MP, Betlloch I, Guijarro J, Vergara G, Pascual JC, Botella R. Severe pruritus in a haemodialysed patient: dramatic improvement with granisetron. British Journal of Dermatology [Internet]. Wiley; 2003 Feb;148(2):376–7. Available from: https://doi.org/10.1046/j.1365-2133.2003.05097_11.x DOI: https://doi.org/10.1046/j.1365-2133.2003.05097_11.x
Peer G, Kivity S, Agami O, Fireman E, Silverberg D, Blum M, et al. Randomised crossover trial of naltrexone in uraemic pruritus. The Lancet [Internet]. Elsevier BV; 1996 Dec;348(9041):1552–4. Available from: https://doi.org/10.1016/s0140-6736(96)04176-1 DOI: https://doi.org/10.1016/S0140-6736(96)04176-1
Wikström B, Gellert R, Ladefoged SD, Danda Y, Akai M, Ide K, et al. κ-Opioid System in Uremic Pruritus: Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Studies. Journal of the American Society of Nephrology [Internet]. American Society of Nephrology (ASN); 2005 Oct 26;16(12):3742–7. Available from: https://doi.org/10.1681/asn.2005020152 DOI: https://doi.org/10.1681/ASN.2005020152
Silva SRB, Viana PCF, Lugon NV, Hoette M, Ruzany F, Lugon JR. Thalidomide for the Treatment of Uremic Pruritus: A Crossover Randomized Double-Blind Trial. Nephron [Internet]. S. Karger AG; 1994;67(3):270–3. Available from: https://doi.org/10.1159/000187978 DOI: https://doi.org/10.1159/000187978
Chan KY, Li CW, Wong H, Yip T, Chan ML, Cheng HW, et al. Use of Sertraline for Antihistamine-Refractory Uremic Pruritus in Renal Palliative Care Patients. Journal of Palliative Medicine [Internet]. Mary Ann Liebert Inc; 2013 Aug;16(8):966–70. Available from: https://doi.org/10.1089/jpm.2012.0504 DOI: https://doi.org/10.1089/jpm.2012.0504
Pederson JA. Relief of Idiopathic Generalized Pruritus in Dialysis Patients Treated with Activated Oral Charcoal. Annals of Internal Medicine [Internet]. American College of Physicians; 1980 Sep 1;93(3):446. Available from: https://doi.org/10.7326/0003-4819-93-3-446 DOI: https://doi.org/10.7326/0003-4819-93-3-446
Kremer AE, Bolier R, van Dijk R, Oude Elferink RPJ, Beuers U. Advances in Pathogenesis and Management of Pruritus in Cholestasis. Digestive Diseases [Internet]. S. Karger AG; 2014;32(5):637–45. Available from: https://doi.org/10.1159/000360518 DOI: https://doi.org/10.1159/000360518
Dogra S, Jindal R. Cutaneous manifestations of common liver diseases. Journal of clinical and experimental hepatology. 2011 Dec 1;1(3):177-84. DOI: https://doi.org/10.1016/S0973-6883(11)60235-1
Beard MP, Millington GW. Recent developments in the specific dermatoses of pregnancy. Clinical and Experimental Dermatology: Clinical dermatology. 2012 Jan;37(1):1-5. DOI: https://doi.org/10.1111/j.1365-2230.2011.04173.x
Goldman RD. The `Butterfly’ Sign. Archives of Dermatology [Internet]. American Medical Association (AMA); 1983 Feb 1;119(2):183. Available from: https://doi.org/10.1001/archderm.1983.01650260091026 DOI: https://doi.org/10.1001/archderm.1983.01650260091026
Quarneti C, Muratori P, Lalanne C, Fabbri A, Menichella R, Granito A, et al. Fatigue and pruritus at onset identify a more aggressive subset of primary biliary cirrhosis. Liver International [Internet]. Wiley; 2014 Apr 23;35(2):636–41. Available from: https://doi.org/10.1111/liv.12560 DOI: https://doi.org/10.1111/liv.12560
Eisendle K, Müller H, Ortner E, Talasz H, Graziadei I, Vogel W, et al. Pruritus of unknown origin and elevated total serum bile acid levels in patients without clinically apparent liver disease. Journal of Gastroenterology and Hepatology [Internet]. Wiley; 2011 Mar 21;26(4):716–21. Available from: https://doi.org/10.1111/j.1440-1746.2010.06522.x DOI: https://doi.org/10.1111/j.1440-1746.2010.06522.x
Tandon P, Rowe BH, Vandermeer B, Bain VG. The Efficacy and Safety of Bile Acid Binding Agents, Opioid Antagonists, or Rifampin in the Treatment of Cholestasis-Associated Pruritus. The American Journal of Gastroenterology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2007 Jul;102(7):1528–36. Available from: https://doi.org/10.1111/j.1572-0241.2007.01200.x DOI: https://doi.org/10.1111/j.1572-0241.2007.01200.x
Di CP, Tritapepe R, Rovagnati P, Rossetti S. Double-blind placebo-controlled clinical trial of microporous cholestyramine in the treatment of intra-and extra-hepatic cholestasis: relationship between itching and serum bile acids. Methods and findings in experimental and clinical pharmacology. 1984 Dec;6(12):773-6
Ghent CN, Carruthers SG. Treatment of pruritus in primary biliary cirrhosis with rifampin. Gastroenterology [Internet]. Elsevier BV; 1988 Feb;94(2):488–93. Available from: https://doi.org/10.1016/0016-5085(88)90442-8 DOI: https://doi.org/10.1016/0016-5085(88)90442-8
Khurana S, Singh P. Rifampin is safe for treatment of pruritus due to chronic cholestasis: a meta-analysis of prospective randomized-controlled trials. Liver International [Internet]. Wiley; 2006 Oct;26(8):943–8. Available from: https://doi.org/10.1111/j.1478-3231.2006.01326.x DOI: https://doi.org/10.1111/j.1478-3231.2006.01326.x
Phan NQ, Bernhard JD, Luger TA, Ständer S. Antipruritic treatment with systemic μ-opioid receptor antagonists: a review. Journal of the American Academy of Dermatology. 2010 Oct 1;63(4):680-8. DOI: https://doi.org/10.1016/j.jaad.2009.08.052
Mayo MJ, Handem I, Saldana S, Jacobe H, Getachew Y, Rush AJ. Sertraline as a first-line treatment for cholestatic pruritus. Hepatology [Internet]. Wiley; 2007;45(3):666–74. Available from: https://doi.org/10.1002/hep.21553 DOI: https://doi.org/10.1002/hep.21553
Bergasa NV, Schmitt JM, Talbot TL, Alling DW, Swain MG, Turner ML, et al. Open-label trial of oral nalmefene therapy for the pruritus of cholestasis. Hepatology [Internet]. Wiley; 1998 Mar;27(3):679–84. Available from: https://doi.org/10.1002/hep.510270307 DOI: https://doi.org/10.1002/hep.510270307
Bergasa NV, Alling DW, Talbot TL, Wells MC, Jones EA. Oral nalmefene therapy reduces scratching activity due to the pruritus of cholestasis: A controlled study. Journal of the American Academy of Dermatology [Internet]. Elsevier BV; 1999 Sep;41(3):431–4. Available from: https://doi.org/10.1016/s0190-9622(99)70117-9 DOI: https://doi.org/10.1016/S0190-9622(99)70117-9
Hohl CM, Wong JK, Harlos MS. Methylnaltrexone to Palliate Pruritus in Terminal Hepatic Disease. Journal of Palliative Care [Internet]. SAGE Publications; 2015 Jun;31(2):124–6. Available from: https://doi.org/10.1177/082585971503100209 DOI: https://doi.org/10.1177/082585971503100209
Joshi GG, Thakur BS, Sircar S, Namdeo A, Jain AK. Role of intravenous naloxone in severe pruritus of acute cholestasis. Indian Journal of Gastroenterology [Internet]. Springer Science and Business Media LLC; 2009 Sep;28(5):180–2. Available from: https://doi.org/10.1007/s12664-009-0070-8 DOI: https://doi.org/10.1007/s12664-009-0070-8
Schwörer H, Hartmann H, Ramadori G. Relief of cholestatic pruritus by a novel class of drugs: 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists: effectiveness of ondansetron. Pain [Internet]. Ovid Technologies (Wolters Kluwer Health); 1995 Apr;61(1):33–7. Available from: https://doi.org/10.1016/0304-3959(94)00145-5 DOI: https://doi.org/10.1016/0304-3959(94)00145-5
Müller C, Pongratz S, Pidlich J, Penner E, Kaider A, Schemper M, et al. Treatment of pruritus in chronic liver disease with the 5-hydroxytryptamine receptor type 3 antagonist ondansetron. European Journal of Gastroenterology & Hepatology [Internet]. Ovid Technologies (Wolters Kluwer Health); 1998 Oct;10(10):865–70. Available from: https://doi.org/10.1097/00042737-199810000-00010 DOI: https://doi.org/10.1097/00042737-199810000-00010
O'Donohue JW, Pereira SP, Ashdown AC, Haigh CG, Wilkinson JR, Williams R. A controlled trial of ondansetron in the pruritus of cholestasis. Alimentary pharmacology & therapeutics. 2005 Apr;21(8):1041-5. DOI: https://doi.org/10.1111/j.1365-2036.2005.02430.x
Jones EA, Molenaar HA, Oosting J. Ondansetron and pruritus in chronic liver disease: a controlled study. Hepato-gastroenterology. 2007 Jun;54(76):1196-9.
Neff GW, O’Brien CB, Reddy KR, Bergasa NV, Regev A, Molina E, et al. Preliminary observation with dronabinol in patients with intractable pruritus secondary to cholestatic liver disease. The American Journal of Gastroenterology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2002 Aug;97(8):2117–9. Available from: https://doi.org/10.1111/j.1572-0241.2002.05852.x DOI: https://doi.org/10.1111/j.1572-0241.2002.05852.x
Bachs L, Elena M, Parés A, Piera C, Rodés J. Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis. The Lancet [Internet]. Elsevier BV; 1989 Mar;333(8638):574–6. Available from: https://doi.org/10.1016/s0140-6736(89)91608-5 DOI: https://doi.org/10.1016/S0140-6736(89)91608-5
Borgeat A, Wilder-Smith O, Mentha G, Huber O. Propofol and cholestatic pruritus. American Journal of Gastroenterology. 1992 May 1;87(5):672–4.
Borgeat A, Savioz D, Mentha G et al. Intractable cholestatic pruritus after liver transplantation—management with propofol. Transplantation [Internet]. Ovid Technologies (Wolters Kluwer Health); 1994 Sep;58(6):727–8. Available from: https://doi.org/10.1097/00007890-199409000-00017 DOI: https://doi.org/10.1097/00007890-199409000-00017
Aguilar-Bernier M, Bassas-Vila J, Sanz-Munoz C, Miranda-Romero A. Successful treatment of pruritus with topical tacrolimus in a patient with primary biliary cirrhosis. British Journal of Dermatology [Internet]. Wiley; 2005 Apr;152(4):808–9. Available from: https://doi.org/10.1111/j.1365-2133.2005.06498.x DOI: https://doi.org/10.1111/j.1365-2133.2005.06498.x
Bergasa NV, McGee M, Ginsburg IH, Engler D. Gabapentin in patients with the pruritus of cholestasis: A double-blind, randomized, placebo-controlled trial. Hepatology [Internet]. Wiley; 2006;44(5):1317–23. Available from: https://doi.org/10.1002/hep.21370 DOI: https://doi.org/10.1002/hep.21370
Hegade VS, Krawczyk M, Kremer AE, Kuczka J, Gaouar F, Kuiper EMM, et al. The safety and efficacy of nasobiliary drainage in the treatment of refractory cholestatic pruritus: a multicentre European study. Alimentary Pharmacology & Therapeutics [Internet]. Wiley; 2015 Nov 2;43(2):294–302. Available from: https://doi.org/10.1111/apt.13449 DOI: https://doi.org/10.1111/apt.13449
Hegade VS, Kendrick SF, Jones DE. Drug treatment of pruritus in liver diseases. Clinical Medicine [Internet]. Royal College of Physicians; 2015 Aug;15(4):351–7. Available from: https://doi.org/10.7861/clinmedicine.15-4-351 DOI: https://doi.org/10.7861/clinmedicine.15-4-351
Yosipovitch G, Samuel LS. Neuropathic and psychogenic itch. Dermatologic Therapy [Internet]. Wiley; 2008 Jan;21(1):32–41. Available from: https://doi.org/10.1111/j.1529-8019.2008.00167.x DOI: https://doi.org/10.1111/j.1529-8019.2008.00167.x
Brenaut E, Nizery-Guermeur C, Audebert-Bellanger S, Ferkal S, Wolkenstein P, Misery L, et al. Clinical Characteristics of Pruritus in Neurofibromatosis 1. Acta Dermato Venereologica [Internet]. Acta Dermato-Venereologica; 2016;96(3):398–9. Available from: https://doi.org/10.2340/00015555-2241 DOI: https://doi.org/10.2340/00015555-2241
Stumpf A, Ständer S. Neuropathic itch: diagnosis and management. Dermatologic Therapy [Internet]. Wiley; 2013 Mar;26(2):104–9. Available from: https://doi.org/10.1111/dth.12028 DOI: https://doi.org/10.1111/dth.12028
Fjellner B, Arnetz BB. Psychological predictors of pruritus during mental stress. Acta dermato-venereologica. 1985;65(6):504-8.
Robinson P, Szewczyk M, Haddy L, Jones P, Harvey W. Outbreak of Itching and Rash. Archives of Internal Medicine [Internet]. American Medical Association (AMA); 1984 Oct 1;144(10):1959. Available from: https://doi.org/10.1001/archinte.1984.04400010067012 DOI: https://doi.org/10.1001/archinte.1984.04400010067012
Schut C, Grossman S, Gieler U, Kupfer J, Yosipovitch G. Contagious itch: what we know and what we would like to know. Frontiers in Human Neuroscience [Internet]. Frontiers Media SA; 2015 Feb 11;9. Available from: https://doi.org/10.3389/fnhum.2015.00057 DOI: https://doi.org/10.3389/fnhum.2015.00057
Niemeier V, Gieler U. Observations during Itch-Inducing Lecture. Dermatology and Psychosomatics / Dermatologie und Psychosomatik [Internet]. S. Karger AG; 2000;1(1):15–8. Available from: https://doi.org/10.1159/000057993 DOI: https://doi.org/10.1159/000057993
Bartels DJP, van Laarhoven AIM, Haverkamp EA, Wilder-Smith OH, Donders ART, van Middendorp H, et al. Role of Conditioning and Verbal Suggestion in Placebo and Nocebo Effects on Itch. Sakakibara M, editor. PLoS ONE [Internet]. Public Library of Science (PLoS); 2014 Mar 19;9(3):e91727. Available from: https://doi.org/10.1371/journal.pone.0091727 DOI: https://doi.org/10.1371/journal.pone.0091727
Gupta M, Gupta A. Stressful major life events are associated with a higher frequency of cutaneous sensory symptoms: an empirical study of non-clinical subjects. Journal of the European Academy of Dermatology and Venereology [Internet]. Wiley; 2004 Sep;18(5):560–5. Available from: https://doi.org/10.1111/j.1468-3083.2004.00931.x DOI: https://doi.org/10.1111/j.1468-3083.2004.00931.x
Verhoeven EW, De Klerk S, Kraaimaat FW, Van De Kerkhof P, De Jong EM, Evers AW. Biopsychosocial mechanisms of chronic itch in patients with skin diseases: a review. Acta dermato-venereologica. 2008 May 1;88(3):211-8.
Kim HJ, Park JB, Lee JH, Kim I-H. How stress triggers itch: a preliminary study of the mechanism of stress-induced pruritus using fMRI. International Journal of Dermatology [Internet]. Wiley; 2015 Aug 14;55(4):434–42. Available from: https://doi.org/10.1111/ijd.12864 DOI: https://doi.org/10.1111/ijd.12864
Kini SP. The Impact of Pruritus on Quality of Life. Archives of Dermatology [Internet]. American Medical Association (AMA); 2011 Oct 1;147(10):1153. Available from: https://doi.org/10.1001/archdermatol.2011.178 DOI: https://doi.org/10.1001/archdermatol.2011.178
Lsheehan-dare RA, henderson MJ, cotterill J. Anxiety and depression in patients with chronic urticaria and generalized pruritus. British Journal of Dermatology [Internet]. Wiley; 1990 Dec;123(6):769–74. Available from: https://doi.org/10.1111/j.1365-2133.1990.tb04195.x DOI: https://doi.org/10.1111/j.1365-2133.1990.tb04195.x
Lopes GB, Nogueira FCP, de Souza MR, Penalva MA, de Amorim JL, Pisoni RL, et al. Assessment of the psychological burden associated with pruritus in hemodialysis patients using the kidney disease quality of life short form. Quality of Life Research [Internet]. Springer Science and Business Media LLC; 2011 Jul 9;21(4):603–12. Available from: https://doi.org/10.1007/s11136-011-9964-x DOI: https://doi.org/10.1007/s11136-011-9964-x
Stumpf A, Ständer S, Warlich B, Fritz F, Bruland P, Pfleiderer B, et al. Relations between the characteristics and psychological comorbidities of chronic pruritus differ between men and women: women are more anxious than men. British Journal of Dermatology [Internet]. Wiley; 2015 Mar 9;172(5):1323–8. Available from: https://doi.org/10.1111/bjd.13492 DOI: https://doi.org/10.1111/bjd.13492
Stumpf A, Ständer S, Phan NQ, Tanneberger A, Heuft G, Schneider G. Body Concept of Patients with Chronic Pruritus in Relation to Scratch Lesions and Psychic Symptoms. Dermatology [Internet]. S. Karger AG; 2013;227(3):263–9. Available from: https://doi.org/10.1159/000354911 DOI: https://doi.org/10.1159/000354911
Misery L, Alexandre S, Dutray S, Chastaing M, Consoli S, Audra H, et al. Functional Itch Disorder or Psychogenic Pruritus: Suggested Diagnosis Criteria From the French Psychodermatology Group. Acta Dermato-Venereologica [Internet]. Acta Dermato-Venereologica; 2007;87(4):341–4. Available from: https://doi.org/10.2340/00015555-0266 DOI: https://doi.org/10.2340/00015555-0266
Kretzmer GE, Gelkopf M, Kretzmer G, Melamed Y. Idiopathic pruritus in psychiatric inpatients: an explorative study. General Hospital Psychiatry [Internet]. Elsevier BV; 2008 Jul;30(4):344–8. Available from: https://doi.org/10.1016/j.genhosppsych.2008.03.006 DOI: https://doi.org/10.1016/j.genhosppsych.2008.03.006
Wallengren J, Ferm I, Sterner M. Somatic and Psychiatric Comorbidity in Patients with Chronic Pruritus. Acta Dermato Venereologica [Internet]. Acta Dermato-Venereologica; 2010;90(4):395–400. Available from: https://doi.org/10.2340/00015555-0864 DOI: https://doi.org/10.2340/00015555-0864
Kimsey L. Delusional Infestation and Chronic Pruritus: A Review. Acta Dermato Venereologica [Internet]. Acta Dermato-Venereologica; 2016;96(3):298–302. Available from: https://doi.org/10.2340/00015555-2236 DOI: https://doi.org/10.2340/00015555-2236
Os-Medendorp H van, Eland-de Kok P, Linge R van, Bruijnzeel-Koomen C, Grypdonck M, Ros W. The tailored implementation of the nursing programme “Coping with itch.”Journal of Clinical Nursing [Internet]. Wiley; 2008 Jun;17(11):1460–70. Available from: https://doi.org/10.1111/j.1365-2702.2007.01982.x DOI: https://doi.org/10.1111/j.1365-2702.2007.01982.x
Van Os-Medendorp H, Eland-de Kok PC, Ros WJ, Bruijnzeel-Koomen CA, Grypdonck M. The nursing programme ?Coping with itch?: a promising intervention for patients with chronic pruritic skin diseases. Journal of Clinical Nursing [Internet]. Wiley; 2007 Jul;16(7):1238–46. Available from: https://doi.org/10.1111/j.1365-2702.2007.01590.x DOI: https://doi.org/10.1111/j.1365-2702.2007.01590.x
Van Os-Medendorp H, Ros WJG, Eland-de Kok PCM, Kennedy C, Thio BH, van der Schuur-van der Zande A, et al. Effectiveness of the nursing programme “Coping with itch”: a randomized controlled study in adults with chronic pruritic skin disease. British Journal of Dermatology [Internet]. Wiley; 2007 Jun;156(6):1235–44. Available from: https://doi.org/10.1111/j.1365-2133.2007.07919.x DOI: https://doi.org/10.1111/j.1365-2133.2007.07919.x
Calabrò RS, Bramanti P, Digangi G, Mondello S, Italiano D. Psychogenic Itch Responding to Topiramate. Psychosomatics [Internet]. Elsevier BV; 2013 May;54(3):297–300. Available from: https://doi.org/10.1016/j.psym.2012.08.006 DOI: https://doi.org/10.1016/j.psym.2012.08.006
Signorelli M, Cinconze M, Nasca M, Marino M, Martinotti G, Giannantonio M, et al. Can Topiramate Induce Pruritus? A Case Report and Review of Literature. CNS & Neurological Disorders - Drug Targets [Internet]. Bentham Science Publishers Ltd.; 2015 Apr 16;14(3):309–12. Available from: https://doi.org/10.2174/1871527314666150225123827 DOI: https://doi.org/10.2174/1871527314666150225123827
Schut C, Mollanazar N, Kupfer J, Gieler U, Yosipovitch G. Psychological Interventions in the Treatment of Chronic Itch. Acta Dermato Venereologica [Internet]. Acta Dermato-Venereologica; 2016;96(2):157–61. Available from: https://doi.org/10.2340/00015555-2177 DOI: https://doi.org/10.2340/00015555-2177
Bonney JHK, Kwame-Aryee RA, Obed S, Tamatey AA, Barnor JS, Armah NB, et al. Fatal hepatitis E viral infection in pregnant women in Ghana: a case series. BMC Research Notes [Internet]. Springer Science and Business Media LLC; 2012 Sep 3;5(1). Available from: https://doi.org/10.1186/1756-0500-5-478 DOI: https://doi.org/10.1186/1756-0500-5-478
Shapiro RS, Samorodin C, Hood AF. Pruritus as a presenting sign of acquired immunodeficiency syndrome. Journal of the American Academy of Dermatology [Internet]. Elsevier BV; 1987 May;16(5):1115–7. Available from: https://doi.org/10.1016/s0190-9622(87)70145-5 DOI: https://doi.org/10.1016/S0190-9622(87)70145-5
Milazzo F, Piconi S, Trabattoni D, Magni C, Coen M, Capetti A, et al. Intractable pruritus in HIV infection: immunologic characterization. Allergy [Internet]. Wiley; 1999 Mar;54(3):266–72. Available from: https://doi.org/10.1034/j.1398-9995.1999.00885.x DOI: https://doi.org/10.1034/j.1398-9995.1999.00885.x
Zuger A. Intolerable pruritus in an HIV-infected man. AIDS clinical care. 1995 Mar;7(3):23-6.
Smith KJ, Skelton HG, Yeager J, Lee RB, Wagner KF. Pruritus in HIV-1 Disease: Therapy with Drugs Which May Modulate the Pattern of Immune Dysregulation. Dermatology [Internet]. S. Karger AG; 1997;195(4):353–8. Available from: https://doi.org/10.1159/000245987 DOI: https://doi.org/10.1159/000245987
Rucklidge JJ, Saunders D. The efficacy of hypnosis in the treatment of pruritus in people with hiv/aids: A time-series analysis. International Journal of Clinical and Experimental Hypnosis [Internet]. Informa UK Limited; 2002 Apr;50(2):149–69. Available from: https://doi.org/10.1080/00207140208410096 DOI: https://doi.org/10.1080/00207140208410096
Lee H-J, Kim G-W, Kim W-J, Mun J-H, Song M, Kim H-S, et al. Clinical characteristics of postherpetic pruritus: assessment using a questionnaire, von Frey filaments and Neurometer. British Journal of Dermatology [Internet]. Wiley; 2015 Apr 1;172(6):1672–3. Available from: https://doi.org/10.1111/bjd.13569 DOI: https://doi.org/10.1111/bjd.13569
Funkhouser TA, Carr WW. A 34-year-old man with chronic itching and peripheral and submucosal eosinophilia. InAllergy and asthma proceedings. 2006 Jan 1;27:77–81.
Awadzi K. Clinical picture and outcome of serious adverse events in the treatment of onchocerciasis. Filaria journal. 2003 Oct 1;2(S1):S6. DOI: https://doi.org/10.1186/1475-2883-2-S1-S6
Kolarova L. Schistosomes causing cercarial dermatitis: a mini-review of current trends in systematics and of host specificity and pathogenicity. Folia Parasitologica [Internet]. Biology Centre, AS CR; 2007 Jun 1;54(2):81–7. Available from: https://doi.org/10.14411/fp.2007.010 DOI: https://doi.org/10.14411/fp.2007.010
Evans AC, Martin DJ, Ginsburg BD. Katayama fever in scuba divers-A report of 3 cases. South African Medical Journal. 1991;79(3):271-4.
Cunha BA, Leonichev VB, Raza M. Chikungunya fever presenting with protracted severe pruritus. IDCases [Internet]. Elsevier BV; 2016;6:29–30. Available from: https://doi.org/10.1016/j.idcr.2016.09.003 DOI: https://doi.org/10.1016/j.idcr.2016.09.003
Trukhan DI. Symptom of itching in the practice of the doctor of the first contact [Symptom sverbizhu v praktytsi likarya pershoho kontaktu] Available from: http://webmedfamily.org/index.php/2014-02-28-13-07-37/stati-i-lektsii/678-simptom-sverbizhu-v-praktitsi-likarya-pershogo-kontaktu
Differential diagnosis of itching [Dyferentsialʹna diahnostyka sverbezhu]. Available from: http://msvitu.com/archive/2013/january/article-1.php
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