Clinical features and outcomes of new daily persistent headache in patients in China and comparison with medication overuse headache: a double-center retrospective study

Authors

  • Huanxian Liu Department of Neurology, The first medical center, The Chinese PLA General Hospital; Medical School of Chinese PLA, Beijing, China
  • Ye Ran Department of Neurology, The first medical center, The Chinese PLA General Hospital; Medical School of Chinese PLA, Beijing, China
  • Liang Dang Department of Neurology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China
  • Ruirui Yang Department of Neurology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China
  • Shuping Sun Department of Neurology, The first medical center, The Chinese PLA General Hospital; Medical School of Chinese PLA, Beijing, China
  • Meichen Zhang Department of Neurology, Beijing Jingmei Group General Hospital, Beijing 100853, China
  • Ke Li Department of Neurology, The first medical center, The Chinese PLA General Hospital; Medical School of Chinese PLA, Beijing, China
  • Chunfu Chen Department of Neurology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China
  • Zhao Dong Department of Neurology, The first medical center, The Chinese PLA General Hospital; Medical School of Chinese PLA, Beijing, China
  • Shengyuan Yu Department of Neurology, The first medical center, The Chinese PLA General Hospital; Medical School of Chinese PLA, Beijing, China

DOI:

https://doi.org/10.31636/pmjua.v6i1.2

Keywords:

new daily persistent headache, medication overuse headache, clinical features, prognosis

Abstract

Background: This study examined the clinical features and outcomes of NDPH patients and comparison with medication-overuse headache (MOH) in Mainland China.

Methods: This retrospective study observed patients with NDPH and medication-overuse headache (MOH) visiting two outpatient clinics between November 2011 and December 2019. Clinical information was collected and all patients were followed by telephone.

Results: The study recruited 73 NDPH and 638 MOH patients. The NDPH patients included 39 males (39/73, 53.4%) and 34 females (34/73, 46.6%), with an average age of 37.4 years and average headache duration of 10.6 years. Headache-precipitating factors included infection (11/73, 15.1%) and stress (22/73, 30.1%). Compared to MOH patients, NDPH patients had a male predominance (53.4% vs. 22.6%, p<0.001), younger age of CDH onset (26.7±12.3 vs. 41.4±11.3 years, p<0.001), and longer duration of CDH (10.6±11.8 vs. 6.1±6.2 years, p=0.023). In 62 NDPH patients followed up for 31 months, on average, therapeutic responses were more effective in NDPH patients with trigger factors than in those without trigger factors (71.4% vs. 32.4%; p = 0.002); the odds ratio (OR) of an effective outcome was 5.25 (1.73–17.84, p = 0.005).

Conclusions: NDPH is significantly different from MOH, with a male predominance, younger age of CDH onset, and longer duration of CDH. The presence of trigger factors is an independent predictor of better treatment effect in NDPH patients.

Downloads

Download data is not yet available.

References

Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia [Internet]. SAGE Publications; 2018 Jan;38(1):1–211. Available from: https://doi.org/10.1177/0333102417738202 DOI: https://doi.org/10.1177/0333102417738202

Yamani N, Olesen J. New daily persistent headache: a systematic review on an enigmatic disorder. The Journal of Headache and Pain [Internet]. Springer Science and Business Media LLC; 2019 Jul 15;20(1). Available from: https://doi.org/10.1186/s10194-019-1022-z DOI: https://doi.org/10.1186/s10194-019-1022-z

Bigal ME, Lipton RB, Tepper SJ, Rapoport AM, Sheftell FD. Primary chronic daily headache and its subtypes in adolescents and adults. Neurology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2004 Sep 13;63(5):843–7. Available from: https://doi.org/10.1212/01.wnl.0000137039.08724.18 DOI: https://doi.org/10.1212/01.WNL.0000137039.08724.18

Takase Y, Nakano M, Tatsumi C, Matsuyama T. Clinical Features, Effectiveness Of Drug-Based Treatment, and Prognosis of New Daily Persistent Headache (NDPH): 30 Cases in Japan. Cephalalgia [Internet]. SAGE Publications; 2004 Nov;24(11):955–9. Available from: https://doi.org/10.1111/j.1468-2982.2004.00771.x DOI: https://doi.org/10.1111/j.1468-2982.2004.00771.x

Dong Z, Di H, Dai W, Liang J, Pan M, Zhang M, et al. Application of ICHD-II Criteria in a Headache Clinic of China. Lakshmana MK, editor. PLoS ONE [Internet]. Public Library of Science (PLoS); 2012 Dec 11;7(12):e50898. Available from: https://doi.org/10.1371/journal.pone.0050898 DOI: https://doi.org/10.1371/journal.pone.0050898

Diener H-C, Holle D, Solbach K, Gaul C. Medication-overuse headache: risk factors, pathophysiology and management. Nature Reviews Neurology [Internet]. Springer Science and Business Media LLC; 2016 Sep 12;12(10):575–83. Available from: https://doi.org/10.1038/nrneurol.2016.124 DOI: https://doi.org/10.1038/nrneurol.2016.124

Yu S, Liu R, Zhao G, Yang X, Qiao X, Feng J, et al. The Prevalence and Burden of Primary Headaches in China: A Population-Based Door-to-Door Survey. Headache: The Journal of Head and Face Pain [Internet]. Wiley; 2011 Dec 28;52(4):582–91. Available from: https://doi.org/10.1111/j.1526-4610.2011.02061.x DOI: https://doi.org/10.1111/j.1526-4610.2011.02061.x

Reidy BL, Riddle EJ, Powers SW, Slater SK, Kacperski J, Kabbouche MA, et al. Clinic-based characterization of continuous headache in children and adolescents: Comparing youth with chronic migraine to those with new daily persistent headache. Cephalalgia [Internet]. SAGE Publications; 2020 Apr 26;40(10):1063–9. Available from: https://doi.org/10.1177/0333102420920644 DOI: https://doi.org/10.1177/0333102420920644

Uniyal R, Paliwal VK, Tripathi A. Psychiatric comorbidity in new daily persistent headache: A cross-sectional study. European Journal of Pain [Internet]. Wiley; 2017 Feb 1;21(6):1031–8. Available from: https://doi.org/10.1002/ejp.1000 DOI: https://doi.org/10.1002/ejp.1000

Rozen TD. Triggering Events and New Daily Persistent Headache: Age and Gender Differences and Insights on Pathogenesis-A Clinic-Based Study. Headache: The Journal of Head and Face Pain [Internet]. Wiley; 2015 Oct 16;56(1):164–73. Available from: https://doi.org/10.1111/head.12707 DOI: https://doi.org/10.1111/head.12707

Robbins MS, Grosberg BM, Napchan U, Crystal SC, Lipton RB. Clinical and prognostic subforms of new daily-persistent headache. Neurology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2010 Apr 26;74(17):1358–64. Available from: https://doi.org/10.1212/wnl.0b013e3181dad5de DOI: https://doi.org/10.1212/WNL.0b013e3181dad5de

Prakash S, Saini S, Rana KR, Mahato P. Refining clinical features and therapeutic options of new daily persistent headache: a retrospective study of 63 patients in India. The Journal of Headache and Pain [Internet]. Springer Science and Business Media LLC; 2012 May 27;13(6):477–85. Available from: https://doi.org/10.1007/s10194-012-0461-6 DOI: https://doi.org/10.1007/s10194-012-0461-6

Peng K-P, Fuh J-L, Yuan H-K, Shia B-C, Wang S-J. New daily persistent headache: Should migrainous features be incorporated? Cephalalgia [Internet]. SAGE Publications; 2011 Sep 29;31(15):1561–9. Available from: https://doi.org/10.1177/0333102411424620 DOI: https://doi.org/10.1177/0333102411424620

Kung E, Tepper S, Rapoport A, Sheftell F, Bigal M. New Daily Persistent Headache in the Paediatric Population. Cephalalgia [Internet]. SAGE Publications; 2009 Jan;29(1):17–22. Available from: https://doi.org/10.1111/j.1468-2982.2008.01647.x DOI: https://doi.org/10.1111/j.1468-2982.2008.01647.x

Diaz-Mitoma F, Vanast W, Tyrrell DJ. Increased frequency of epstein-barr virus excretion in patients with new daily persistent headaches. The Lancet [Internet]. Elsevier BV; 1987 Feb;329(8530):411–5. Available from: https://doi.org/10.1016/s0140-6736(87)90119-x DOI: https://doi.org/10.1016/S0140-6736(87)90119-X

Meineri P, Torre E, Rota E, Grasso E. New daily persistent headache: clinical and serological characteristics in a retrospective study. Neurological Sciences [Internet]. Springer Science and Business Media LLC; 2004 Oct;25(S3):s281–s282. Available from: https://doi.org/10.1007/s10072-004-0310-8 DOI: https://doi.org/10.1007/s10072-004-0310-8

Abreu LV, Oliveira CB, Bordini CA, Valença MM. New Daily Persistent Headache Following Dengue Fever: Report of Three Cases and an Epidemiological Study. Headache: The Journal of Head and Face Pain [Internet]. Wiley; 2019 Dec 27;60(1):265–8. Available from: https://doi.org/10.1111/head.13718 DOI: https://doi.org/10.1111/head.13718

Rozen TD. New daily persistent headache (NDPH) triggered by a single Valsalva event: A case series. Cephalalgia [Internet]. SAGE Publications; 2018 Oct 9;39(6):785–91. Available from: https://doi.org/10.1177/0333102418806869 DOI: https://doi.org/10.1177/0333102418806869

Evers S, Marziniak M. Clinical features, pathophysiology, and treatment of medication-overuse headache. The Lancet Neurology [Internet]. Elsevier BV; 2010 Apr;9(4):391–401. Available from: https://doi.org/10.1016/s1474-4422(10)70008-9 DOI: https://doi.org/10.1016/S1474-4422(10)70008-9

Hagen K, Vatten L, Stovner L, Zwart J-A, Krokstad S, Bovim G. Low Socio-Economic Status is Associated with Increased Risk of Frequent Headache: A Prospective Study of 22718 Adults in Norway. Cephalalgia [Internet]. SAGE Publications; 2002 Oct;22(8):672–9. Available from: https://doi.org/10.1046/j.1468-2982.2002.00413.x DOI: https://doi.org/10.1046/j.1468-2982.2002.00413.x

Rozen TD. The Three T's of NDPH (How Clinical Observations Have Led to Improved Treatment Outcomes). Headache. 2019;59(8):1401-6. Available from: https://doi.org/10.1111/head.13624 DOI: https://doi.org/10.1111/head.13624

Prakash S, Golwala P. Phantom headache: pain-memory-emotion hypothesis for chronic daily headache? The Journal of Headache and Pain [Internet]. Springer Science and Business Media LLC; 2011 Apr 9;12(3):281–6. Available from: https://doi.org/10.1007/s10194-011-0307-7 DOI: https://doi.org/10.1007/s10194-011-0307-7

Li D, Rozen T. The Clinical Characteristics of New Daily Persistent Headache. Cephalalgia [Internet]. SAGE Publications; 2002 Feb;22(1):66–9. Available from: https://doi.org/10.1046/j.1468-2982.2002.00326.x DOI: https://doi.org/10.1046/j.1468-2982.2002.00326.x

Clinical features and outcomes of new daily persistent  headache in patients in China and comparison with medicationoveruse headache: a double-center retrospective study

Downloads

Published

2021-04-29

How to Cite

1.
Liu H, Ran Y, Dang L, Yang R, Sun S, Zhang M, Li K, Chen C, Dong Z, Yu S. Clinical features and outcomes of new daily persistent headache in patients in China and comparison with medication overuse headache: a double-center retrospective study. PMJUA [Internet]. 2021 Apr. 29 [cited 2021 Jun. 21];6(1):10-2. Available from: https://painmedicine.org.ua/index.php/pnmdcn/article/view/246

Issue

Section

Original article