The Comparison of Neutropenia and Peripheral Neuropathy Condition as an Impact of 3-hours and 24-hour Paclitaxel Infusion of Paclitaxel-Carboplatin Chemotherapy on Ovarian Cancer Patients

  • Primandono Perbowo Gynaecologic Oncology Division, Dept. Obstetrics and Gynaecology Airlangga University, dr. Soetomo Surabaya Public Hospital, Indonesia
  • Brahmana Askandar Gynaecologic Oncology Division, Dept. Obstetrics and Gynaecology Airlangga University, dr. Soetomo Surabaya Public Hospital, Indonesia
  • Ratna Soebady Gynaecologic Oncology Division, Dept. Obstetrics and Gynaecology Airlangga University, dr. Soetomo Surabaya Public Hospital, Indonesia
  • Ahcmad Bashory Gynaecologic Oncology Division, Dept. Obstetrics and Gynaecology Airlangga University, dr. Soetomo Surabaya Public Hospital, Indonesia
Keywords: Neutropenia, Peripheral Neuropathy, Paclitaxel, Carboplatin, Ovarian Carcinoma, Neuro Conduction Study

Abstract

This study is aimed to compare the difference of neutropenia with peripheral neuropathy condition, after administration of 3 hours and 24 hours Paclitaxel infusion in adjuvant therapy with Paclitaxel­Carboplatin toward patient with ovarian carcinoma. The method that used was experimental research with samples randomized after consecutively recruited based on inclusive criteria. Before and every after chemotherapy, NCS was performed and differential count laboratories’ test and then analysed with T­test and Chi­square test. The result showed that from three times administration of 3 hours Paclitaxel­Carboplatin infusion group, the neutropenia condition after first up to third chemotherapy was 20 %, 30 %, 30 %, and the peripheral neuropathy condition was 30 %, 60 %, 50 % respectively. Meanwhile, in 24 hours Paclitaxel­Carboplatin infusion group, the incident of neutropenia after first up to third chemotherapy was 40 %, 50 %, 40 %, and the incident of peripheral neuropathy was 20 %, 20 %, 20 % respectively. The statistic result was p > 0.05. Hence, there was no significant difference in neutropenia and peripheral neuropathy incident on two study group.

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The Comparison of Neutropenia and Peripheral Neuropathy Condition as an Impact of 3-hours and 24-hour Paclitaxel Infusion of Paclitaxel-Carboplatin Chemotherapy  on Ovarian Cancer Patients
Published
2019-07-15
How to Cite
1.
Perbowo P, Askandar B, Soebady R, Bashory A. The Comparison of Neutropenia and Peripheral Neuropathy Condition as an Impact of 3-hours and 24-hour Paclitaxel Infusion of Paclitaxel-Carboplatin Chemotherapy on Ovarian Cancer Patients. PMJUA [Internet]. 2019Jul.15 [cited 2019Sep.21];4(2):41-2. Available from: https://painmedicine.org.ua/index.php/pnmdcn/article/view/197
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