Submission of the use of the method of preemtive analgesia with acetaminophen for perioperative period in children

  • D V Dmytriiev Vinnytsia National Pirogov Memorial Medical University https://orcid.org/0000-0001-6067-681X
  • O V Marchuk Vinnytsia National Pirogov Memorial Medical University
  • V L Vitkovskyi Vinnytsia National Pirogov Memorial Medical University
  • V Yu Kebenko Vinnytsia National Pirogov Memorial Medical University
Keywords: analgesia, pain, postoperative period, children

Abstract

In the structure of postoperative anesthesia in children, as well as in other age groups, the main place is occupied by narcotic analgesics; the route of administration is traditional– intramuscular. The purpose of the study was to in-crease the effectiveness of postoperative analgesia with opioid analgesics in children. The study was conducted in 37 children with a mean age of 3.2 ± 0.8 years operated on tumors in the peritoneal space (27 children, 73%), kidney tumors (8chil-dren, 22%) and ovarian tumors (2 children, 5%). Comprehensive study of the reactions of pain behavior, physiological parameters and laboratory stress tests showed that the use of the scheme of analgesia based on acetaminophen 30 mg/kg and the method of continuous infusion of drugs (fentanyl in a dose of 5 μg/kg/h) for postoperative anesthesia leads to effective analgesia after traumatic operations in the neonatal period. The use of the method of continuous intravenous infusion of opioid analgesics leads to a pronounced, to varying degrees, sedation and respiratory depression, which enables children to adapt well to the apparatus of mechanical ventilation after various surgical interventions.

Downloads

Download data is not yet available.

References

Ветешев ПС, Ветешева МС. Принципы анальгезии в раннем послеоперационном периоде. Хирургия.2002;12:49–52.

Лекманов АУ. Внутривенное использование трамадола для послеоперационной анальгезии у детей. Омск. Материалы VIII Всероссийского съезда анестезиологов реаниматологов; 1999:14–7.

Осипова НА, Никода ВВ. Современное состояние науки о боли. Острые и хронические болевые синдромы. Анестезиология иреаниматология.2003;5:4–9.

Дж. Эдвард Морган-мл., Мэгид С.Михаил. Клиническая анестезиология. М.: издательство Бином; 2003. Т. 3.С. 298.

Караваева СА, Баиров ВГ, Немилова ТК. Лечение гастрошизиса. Детская хирургия.1998;3:4–7.

Woolf CJ, Chong MS. Preemptive analgesia– treating postoperative pain by preventing the establishment of central sensitization. Anesth. Analg.1993;V.77:1–18.

Eide PK, Stubhaug A, Qye I. The NMDA-antagonist ketamine for prevention and treatment of acute and chronic postoperative pain. Bailliere’s Clin. Anaesthesiol. 1995;V.9(3):539–53.

Brennum J, Petersen KL, Horn A et al. Quantitative sensory ex-amination of epidural anaesthesia and analgesia in man: combination of morphine and bupivacaine. Pain.1994;V.56:327–337.

Нестероидные противовоспалительные средства в терапии онкологической боли. На чем остановить выбор? Обезболивание в хирургии и интенсивной терапии. Хирургия. 2006; 08(2).

Vittinghoff M, Simic D, Dmytriiev D et al. Postoperative pain management in children: Guidance from the pain committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative). Pediatric Anesthesia. 2018;28(6):493–506.

Hopf H, Weitz J. Postoperative pain management. Arch. Surg. 1994;V. 129(2):128–32.

Kalso E, Perttunen К, Kaasinen S. Pain after thoracic surgery. Acta Anaesth. Scand. 1992;V.36:96–100.

Обґрунтування використання методу преемтив-анальгезії ацетамінофеном для періопераційного знеболення у дітей
Published
2019-02-21
How to Cite
1.
Dmytriiev DV, Marchuk OV, Vitkovskyi VL, Kebenko VY. Submission of the use of the method of preemtive analgesia with acetaminophen for perioperative period in children. PMJUA [Internet]. 21Feb.2019 [cited 24May2019];3(4):65-9. Available from: https://painmedicine.org.ua/index.php/pnmdcn/article/view/168
Section
Original article