Experience in the local use of 0.25% bupivacaine for the treatment of postoperative pain


  • Y N Babina National Pirogov Memorial Medical University, Vinnytsia, Ukraine
  • V S Konoplitsky National Pirogov Memorial Medical University, Vinnytsia, Ukraine
  • O O Kalinchuk National Pirogov Memorial Medical University, Vinnytsia, Ukraine
  • D V Dmytriiev National Pirogov Memorial Medical University, Vinnytsia, Ukraine https://orcid.org/0000-0001-6067-681X
  • O A Nazarchuk National Pirogov Memorial Medical University, Vinnytsia, Ukraine
  • E V Andriets National Pirogov Memorial Medical University, Vinnytsia, Ukraine




local anesthetics, bupivacaine, postoperative pain


According to British scientists, about 300 million operations are performed around the world annually. They cause acute postoperative pain, the management of which is crucial for improving patient outcomes and reducing healthcare costs. Local anesthetic infiltration before closing the surgical incision is a commonly used technique in the operating room. This review focuses on the use of local anesthetic infiltration, 0.25% bupivacaine, into surgical incisions to reduce postoperative pain, as confirmed by an estimate of a reduction in the use of postoperative opioids and a visual analogue scale (VAS). The presented clinical cases and the combined analgesia scheme with infiltration of a local anesthetic into the postoperative wound were used to make it possible to argue about the effectiveness of anesthesia because on the peripheral mechanism of pain. Infiltration analgesia reduced the need for opioids and the time of stay in hospitals. It was concluded that there is a need for further research on methods of delivering anesthetics to postoperative wounds for pain management and improving the quality of treatment.


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LeBlanc K, M. Sweitzer S. Systematic Review of Clinical Evidence for Local Anesthetic Wound Infiltration in Reduction of Post-Surgical Pain. Internal Medicine: Open Access [Internet]. OMICS Publishing Group; 2015;05(06). Available from: https://doi.org/10.4172/2165-8048.1000207

Johnson RC, Hedges AR, Morris R, Stamatakis JD. Ideal pain relief following laparoscopic cholecystectomy. Int J Clin Pract. 1999 Jan-Feb;53(1):16-8.

LeBlanc KJ. The Effectiveness of Local Anesthetic Infiltration into a Surgical Wound Prior to Surgical Closure; 2014:1–7.

Tintinally J, Stapczynski J. Tintinalli's Emergency Medicine. 7th ed. New York: McGraw-Hill Education; 2010.

Kvolik S, et al. A wound infiltration as a method of postoperative analgesia. Periodicum biologorum: 2009; 111(2): 241–6.

Dumlu EG, Tokac M, Ocal H, Durak D, Kara H, Kilic M, et al. Local bupivacaine for postoperative pain management in thyroidectomized patients: A prospective and controlled clinical study. Turkish Journal of Surgery [Internet]. AVES Publishing Co.; 2016 Jul 28;32(3):173–7. Available from: https://doi.org/10.5152/ucd.2015.3138

Massaro F. Liposomal bupivacaine: a long-acting local anesthetic for postsurgical analgesia. Formulary. 2012; 47(6): 212–23.

Cullen KA, Hall MJ, Golosinskiy A. Ambulatory surgery in the United States, 2006. Natl Health Stat Report. 2009 Jan 28;11):1-25.

Chou R, Fanciullo GJ, Fine PG, Adler JA, Ballantyne JC, Davies P, et al. Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain. The Journal of Pain [Internet]. Elsevier BV; 2009 Feb;10(2):113–130.e22. Available from: https://doi.org/10.1016/j.jpain.2008.10.008

White PF. Multimodal analgesia: its role in preventing postoperative pain. Curr Opin Investig Drugs. 2008 Jan;9(1):76-82.

Scott J, Huskisson EC. Graphic representation of pain. Pain. 1976 Jun;2(2):175-84.

Gray A, Kehlet H, Bonnet F, Rawal N. Predicting postoperative analgesia outcomes: NNT league tables or procedure-specific evidence?. British Journal of Anaesthesia [Internet]. Elsevier BV; 2005 Jun;94(6):710–4. Available from: https://doi.org/10.1093/bja/aei144

Bertini L, Mancini S, Di Benedetto P, Ciaschi A, Martini O, Nava S, et al. Postoperative analgesia by combined continuous infusion and patient-controlled epidural analgesia (PCEA) following hip replacement: ropivacaine versus bupivacaine. Acta Anaesthesiol Scand. 2001 Jul;45(6):782-5.

Babak OI, Bilovol OM, Chekman IS. Klinichna farmakolohiia (Clinical Pharmacology). Kyiv: Medytsyna; 2008. p. 79–85.

Досвід місцевого використання 0,25% бупівакаїну для лікування післяопераційного больового синдрому



How to Cite

Babina YN, Konoplitsky VS, Kalinchuk OO, Dmytriiev DV, Nazarchuk OA, Andriets EV. Experience in the local use of 0.25% bupivacaine for the treatment of postoperative pain. PMJUA [Internet]. 2019 Jun. 4 [cited 2023 Feb. 8];4(1):17-23. Available from: https://painmedicine.org.ua/index.php/pnmdcn/article/view/187



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