Analysis of onset time and intubating conditions following intravenous administration of Rocuronium 0.6mg/kg and Rocuronium 0.9mg/kg doses and its comparison with Succinylcholine 1.5mg/kg for Rapid Sequence Induction

Nuthalapaty Syama Kumar; Chandra Sekhar Gangula; Praveen Kumar Naik Badavath; Deepthi Kallam; Bhimeswar M V

doi:10.31636/pmjua.v7i4.2

Автор(и)

Nuthalapaty Syama Kumar Associate Professor, Department of Anaesthesia, Guntur Medical College, Guntur, A.P. INDIA
Chandra Sekhar Gangula Assistant Professor, Department of Anaesthesia, Guntur Medical College, Guntur, A.P. INDIA.
Praveen Kumar Naik Badavath Assistant Professor Department of Anaesthesia, Guntur Medical College, Guntur, A.P. INDIA.
Deepthi Kallam Postgradueate,Department of Anaesthesia, Guntur Medical College, Guntur, A.P. INDIA.
Bhimeswar M V Professor &HOD, Department of Anaesthesia, Guntur Medical College, Guntur, A.P. INDIA.

DOI:

https://doi.org/10.31636/pmjua.v7i4.2

Ключові слова:

швидка послідовна індукція, сукцинілхоліну хлорид, рокуронію бромід, інтубація

Анотація

Довідкова інформація: метою цього дослідження було порівняння рокуронію та сукцинілхоліну у дорослих пацієнтів, яким проводили планову операцію, використовуючи дві різні дози 0,6 мг/кг та 0,9 мг/кг для швидкої послідовної ендотрахеальної інтубації.

Методологія: 90 випадків випадковим чином розділили на три групи по 30 у кожній. Групу S інтубували 1,5 мг сукцинілхоліну хлориду на кг маси тіла, групу R1 інтубували 0,6 мг рокуронію броміду на кг маси тіла, а групу R2 інтубували 0,9 мг рокуронію броміду на кг маси тіла.

Результати: 90 % у групі S, 53,33 % у групі R1 та 76,67 % у групі R2 мали різні умови інтубації. Час початку дії доз групи S був значно коротшим, ніж у групі R2 і R1. Спостерігалася статистично значуща різниця між групою S, групою R1 і групою R2 щодо клінічного початку дії (45,58 ± 4,198, 56,38 ± 5,032 і 52,59 ± 3,966 секунд). Група S, група R1 і група R2 мали середню тривалість дії 5,24 ± 1,453, 23,96 ± 2,14 і 43,18 ± 2,12 хвилин відповідно. У групі R1 і R2 середня частота серцевих скорочень зросла на 47,1 % і 33,9 %, а середній артеріальний тиск підвищився на 28,56 % і 24,92 %, що спостерігалося через одну хвилину після інтубації, і повернувся до рівня перед індукцією через 5 хвилин. У всіх трьох групах суттєвих побічних ефектів не спостерігалося.

Висновок: рокуроній у дозі 0,9 мг/кг є кращим і альтернативним сукцинілхоліну у випадках, коли сукцинілхолін протипоказаний.

Завантаження

Дані завантаження ще не доступні.

Посилання

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