Dexmedetomidine as a component of anesthesia in surgical oncology

Authors

  • I. I. Lisniy National Cancer Institute, Kyiv, Ukraine
  • Kh. A. Zakalska National Cancer Institute, Kyiv, Ukraine

Keywords:

dexmedetomidine, sevoflurane, epidural anesthesia, oncological proctology

Abstract

The efficacy and safety of the use of dexmedetomidine for anesthetic maintenance of colorectal manifestations in surgical oncology was investigated. It is shown that the use of dexmedetomidine contributes to a significant reduction of fentanyl dose. And the opioid-preserving effect is more significant by intravenous dexmedetomidine in comparison with epidural use. Dexmedetomidine does not cause significant depression of hemodynamic parameters and contributes to a stable sedation level, which makes it a promising component of multimodal anesthesia.

Downloads

Download data is not yet available.

References

Sebastien Antoni, Isabelle Soerjomataram, Bjørn Møller et al. An assessment of GLOBOCAN methods for deriving national estimates of cancer incidence // Bulletin of the World Health Organization. – 2016. –94 : 174–184.

Shakhar G., Ben-Eliyahu S. Potential prophylactic measures against рostoperative immunosuppression : could they reduce recurrence rates in oncological patients? // Ann. Surg. Oncol. –2003. – 10 : 972–992.

Hansdottir V., Philip J., Olsen M. Thoracic epidural versus intravenous patient-controlled analgesia after cardiac surgery: a randomized controlled trial on length of hospital stay and patient-perceived quality of recovery // Anesthesiology. –2006. – 104 : 142–151.

Lai R., Peng Z., Chen D. The effects of anesthetic technique on cancer recurrence in percutaneous radiofrequency ablation of small hepatocellular carcinoma // Anesth. Analg. – 2012. – 114 : 290–296.

Cummings K., Xu F., Cummings L., Cooper G. A comparison of epidural analgesia and traditional pain management effects on survival and cancer recurrence after colectomy: a population-based study // Anesthesiology. –2012. – 116 : 797–806.

Heaney A., Buggy D. Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis? // Br. J. Anaesth. –2012. – 109 : 17–28.

Biki B., Mascha E., Moriarty D. et al. Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis // Anesthesiology. –2008. – 109 : 180–7.

Exadaktylos A., Buggy D., Moriarty D. Can аnesthetic technique for primary breast cancer surgery affect recurrence or metastasis? // Anesthesiology. –2006. – 105 : 660–4.

Lin L., Liu C., Tan H. et al. Anaesthetic technique may affect prognosis for ovarian serous adenocarcinoma: a retrospective analysis // Br. J. Anaesth. –2011. – 106 : 814–22.

Bar-Yosef S., Melamed R., Page G. et al. Attenuation of the tumor-promoting effect of surgery by spinal blockade in rats // Anesthesiology. –2001. – 94 : 1066–73.

Melamed R., Bar-Yosef S., Shakhar G. et al. Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures // Anesth. Analg. –2003. – 97 : 1331–9.

Kavanagh T., Buggy D. Can anaesthetic technique effect postoperative outcome? // Curr. Opin. Anaesth. –2012. – 25 : 185–198.

Gottschalk A., Sharma S., Ford J. et al. Review article: the role of the perioperative period in recurrence after cancer surgery // Anesth. Analg. –2010. – 110(6) : 1636–43.

Gupta K., Kshirsagar S., Chang L., Schwartz R. Morphine Stimulates Angiogenesis by Activating Proangiogenic and Survivalpromoting Signaling and Promotes Breast Tumor Growth // Cancer research. –2002. – 62 : 4491–4498.

Elhakim M., Abdelhamid D., Abdelfattach B. et al. Effect of epidural dexmedetomidine on intraoperative awareness and post- operative pain after one-lung ventilation // Acta Anaesthesiol. Scand. –2010. – 54(6) : 703–9.

Bajwa S., Arora V., Parmar S.S. Comparative evaluation of dexmedetomidine and fentanyl for epidural analgesia in lower limb orthopedic surgeries // Saudi J. Anaesth. – 2011. – 5(4) : 365–370.

Bhana N, Goa K. L., McClellan K. J. Dexmedetomidine // Drugs. –2011. – 59 : 263–70.

Jaakola M. L., Salonen M., Lehtinen R., Scheinin H. The analgesic action of dexmedetomidine: A novel alpha-2-adrenoceptor agonist – in healthy volunteers // Pain. –1991. – 46 : 281–5.

Talke P., Richardson C. A., Scheinin M., Fisher D. M. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine // Anesth. Analg. –1997. – 85 : 1136–42.

Gupta R., Bogra J., Verma R. Dexmedetomidine as an intrathecal adjuvant for postoperative analgesia // Indian J. Anaesth. –2011. – 55(4) : 347–351.

Bogetz M. S., Katz J. A. Recall of surgery for major trauma // Anesthesiology. –1984. – 61(1): 6–9.

Guo T. Z., Jiang J. Y., Buttermann A. E., Maze M. Dexmedetomidine injection into the locus coeruleus produces antinociception // Anesthesiology. –1996. – 84(4) : 873–81.

Khan Z. P., Ferguson C. N., Jones R. M. Alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role // Anaesthesia. – 1999. – 54(2): 146–65.

Asano, Toshio А., Shuji D., Shuichiro O., Shimonaka O. Antinociception by epidural and systemic α2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain // Anesth. Analg. –2000. – 90(2) : 400–407.

Saadawy I., Boker A., Elshahawy M. A. et al. Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in paediatrics // Acta Anaesthesiol. Scand. –2009. – 53 (2) : 251–6.

Gurbet A., Basagan-Mogol E., Turker G. et al. Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements // Can. J. Anaesth. –2006. – 53 (7) : 646–52.

Lin T. F., Yeh Y. C., Lin F. S. et al. Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia // Br. J. Anaesth. – 2009. – 102 (1) : 117–22.

Kurosawa S., Kato M. Anesthetics, immune cells, and immune responses //. J. Anesth. –2008. – 22 : 263–277.

Michael D., Brigitte V. Surgical trauma: hyperinflammation versus immunosuppression? // Langenbecks Arch Surg. – 2004. – 389 : 475–484.

Гриневич Ю. А., Барабой В. А. Новообразовательный процесс и стрессовая патология. – К. : Логос, 2010. – 155 с.

Meiler S. Long-term outcome after anesthesia and surgery: remarks on the biology of a newly emerging principle in perioperative care // Anesthesiology Clin N Am. –2006. – 24 : 255–278.

Homburger J., Meiler S. Anesthesia drugs, immunity, and long-term outcome // Curr. Opin. Anesth. – 2006. – 19 : 423–428.

Kusmartsev S., Gabrilovich D. Immature myeloid cells and cancer-associated immune suppression // Cancer Immunol. Immunother. –2006. – 51 : 293–8.

Page G. G. Surgery-induced immunosuppression and postoperative pain management // AACN Clin. Issues. – 2005. – 16 : 302– 9.

Al-Hasani R., Bruchas M. Molecular mechanisms of opioid Receptor dependent signaling and behavior // Anesthesiology. – 2011. – 115 : 1363– 1381.

Martin J., Koodie L., Krishnan A. et al. Chronic morphine administration delays wound healing by inhibiting immune cell recruitment to the wound site // Am. J. Pathol. – 2010. – 176 : 786–799.

Yuan F., Xiaozhou H., Yilin Y. Current Research on Opioid Receptor Function // Curr Drug Targets. – 2012. – 13(2) : 230–246.

Welters I., Menzebach A., Goumon Y. et al. Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and μ3 oipate receptor-dependent mechanism // J. Neuroimmunol. – 2000. – 111 : 139–145.

Mojadadi S., Jamali A., Khansarinejad B. et al. Acute morphine administration reduces cell-mediated immunity and induces reactivation of latent herpes simplex virus type 1 in BALB/c mice // Cell Mol Immunol. –2009. – 6 : 111–116.

Bӧrner C., Warnick B., Smida M. et al. Mechanisms of opioid-mediated inhibition of human T cell receptor signaling // J. Immun. –2011. – 183 : 882–889.

Bӧrner C., Kraus J., Bedini A. et al. T-cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional μ-opioid receptors // Mol Pharmacol. –2008. – 74 : 496–504.

Sacerdote P. Opioid-induced immunosuppression // Curr. Opin. Support Palliat. –2008. – Care, 2 : 14–18.

Published

2017-03-01

How to Cite

1.
Lisniy II, Zakalska KA. Dexmedetomidine as a component of anesthesia in surgical oncology. PMJUA [Internet]. 2017 Mar. 1 [cited 2024 Mar. 29];2(1):34-40. Available from: https://painmedicine.org.ua/index.php/pnmdcn/article/view/44

Similar Articles

1 2 3 4 5 6 7 8 9 > >> 

You may also start an advanced similarity search for this article.