Modern approaches to diagnostics and treatment of migraine in children
Keywords:migraine, treatment, children
This article reviews modern approaches to diagnostics and treatment of a very common and simultaneously underestimated and often maltreated disorder in children. It is fallacious management of migraine masked behind the diagnoses such as autonomic vessel dysfunction and vascular headache here in Ukraine. This is a tremendous problem and it should be solved with appropriate information spread across the medical community.
Up-to-date classification according to the International Headache Society, diagnostic criteria, differential diagnosis, investigation and treatment strategies are presented in the article. All supported data are com-pliant with guidelines of developed countries with evidence-based medicine (US, Canada, Great Britain, Japan, Australia, New Zealand) enhanced with new trials and approved methods. Migraine management is a rapidly evolving concept, where major changes were done during recent years (transcranial Deep Brain Stimulation, vagus stimulation, CGRP-receptor mono-clonal antibodies).
Considering disorder incidence and its impact on life quality and the existence of options for alleviating symptoms, this information is important for physicians who work with children, especially for general practitioners, pediatrics, pediatric and adult neurologists.
Atlas of headache disorders and resources in the world 2011. Geneva: World Health Organization; 2011.
Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia [Internet]. SAGE Publications; 2018 Jan;38(1):1–211. Available from: https://doi.org/10.1177/0333102417738202
Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet [Internet]. Elsevier BV; 2016 Oct;388(10053):1545–602. Available from: https://doi.org/10.1016/s0140-6736(16)31678-6
Clinical Practice Guideline for Chronic Headache 2013, Japanese Society of Neurology, Japanese Headache Society, Guideline Executive Committee. Available at: http://www.jhsnet.org/english/guide-line2013.pdf
G Freitag F, Schloemer F. Recent developments in the treatment of migraine in children and adolescents. Journal of Headache & Pain Management [Internet]. OMICS Publishing Group; 2016;1(2). Available from: https://doi.org/10.4172/2472-1913.100009
The International Classification of Headache Disorders 3rd edition [Internet]. ICHD. Available from: https://www.ichd-3.org/
Beran RG. Management of chronic headache. Aust Fam Physician. 2014 Mar;43(3):106-10.
Headache, Clinical Practice Guidelines, The Royal Children’s Hospital Melbourne. Available at: https://www.rch.org.au/clinicalguide/guideline_index/Headache
Forsyth PA, Posner JB. Headaches in patients with brain tumors: A study of 111 patients. Neurology [Internet]. Ovid Technologies (Wolters Kluwer Health); 1993 Sep 1;43(9):1678–1678. Available from: https://doi.org/10.1212/wnl.43.9.1678
European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis – endorsed by the European Academy of Neurology, 20 August 2017. Available at: http://onlineli-brary.wiley.com/doi/10.1111/ene.13381/full
Ichord R. Cerebral Sinovenous Thrombosis. Frontiers in Pediatrics [Internet]. Frontiers Media SA; 2017 Jul 27;5. Available from: https://doi.org/10.3389/fped.2017.00163
Stence NV, Fenton LZ, Goldenberg NA, Armstrong-Wells J, Bernard TJ. Craniocervical Arterial Dissection in Children: Diagnosis and Treatment. Current Treatment Options in Neurology [Internet]. Springer Science and Business Media LLC; 2011 Oct 7;13(6):636–48. Available from: https://doi.org/10.1007/s11940-011-0149-2
Powers SW, Coffey CS, Chamberlin LA, Ecklund DJ, Klingner EA, Yankey JW, et al. Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine. New England Journal of Medicine [Internet]. Massachusetts Medical Society; 2017 Jan 12;376(2):115–24. Available from: https://doi.org/10.1056/nejmoa1610384
Headaches in over 12s: diagnosis and management, Clinical guideline [CG150] Published date: September 2012 Last updat-ed: November 2015, NICE. Available at: https://www.nice.org.uk/guidance/cg150/chapter/Recommendations
Kinfe TM, Pintea B, Muhammad S, Zaremba S, Roeske S, Simon BJ, et al. Cervical non-invasive vagus nerve stimulation (nVNS) for preventive and acute treatment of episodic and chronic migraine and migraine-associated sleep disturbance: preliminary findings from a prospective observational cohort study. The Journal of Headache and Pain [Internet]. Springer Nature; 2015 Dec;16(1). Available from: https://doi.org/10.1186/s10194-015-0582-9
FDA Clears Vagus Nerve Stimulator for Migraine Pain, Deborah Brauser, January 29, 2018. Available at: https://www.medscape.com/viewar-ticle/891930
Current management of amaurosis fugax. The Amaurosis Fugax Study Group. Stroke [Internet]. Ovid Technologies (Wolters Kluwer Health); 1990 Feb;21(2):201–8. Available from: https://doi.org/10.1161/01.str.21.2.201
Silberstein SD, Dodick DW, Bigal ME, Yeung PP, Goadsby PJ, Blankenbiller T, et al. Fremanezumab for the Preventive Treatment of Chronic Migraine. New England Journal of Medicine [Internet]. Massachusetts Medical Society; 2017 Nov 30;377(22):2113–22. Available from: https://doi.org/10.1056/nejmoa1709038
Teleanu RI, Vladacenco O, Teleanu DM, Epure DA. Treatment of Pediatric Migraine: a Review. Maedica (Buchar). 2016 Jun;11(2):136-43.
Getzoff M, Goldstein B. Spontaneous Subarachnoid Hemorrhage in Children. Pediatrics in Review [Internet]. American Academy of Pediatrics (AAP); 1999 Dec;20(12):422–422. Available from: https://doi.org/10.1542/pir.20-12-422
Mahady K, Thust S, Berkeley R, Stuart S, Barnacle A, Robertson F, et al. Vascular anomalies of the head and neck in children. Quant Imaging Med Surg. 2015 Dec;5(6):886-97.
Jahn K, Langhagen T, Schroeder AS, Heinen F. Vertigo and Dizziness in Childhood − Update on Diagnosis and Treatment. Neuropediatrics [Internet]. Georg Thieme Verlag KG; 2011 Jul 15;42(04):129–34. Available from: https://doi.org/10.1055/s-0031-1283158
Gelfand A. Pathophysiology, clinical features, and diagnosis of migraine in children.
Weiller C, May A, Limmroth V, Jüptner M, Kaube H, Schayck RV, et al. Brain stem activation in spontaneous human migraine attacks. Nature Medicine [Internet]. Springer Nature; 1995 Jul;1(7):658–60. Available from: https://doi.org/10.1038/nm0795-658
Rowe E, Cooper TE, McNicol ED. Ketorolac for postoperative pain in children. Cochrane Database of Systematic Reviews [Internet]. Wiley; 2016 Jul 26; Available from: https://doi.org/10.1002/14651858.cd012294
Starling AJ, Tepper SJ, Marmura MJ, Shamim EA, Robbins MS, Hindiyeh N, et al. A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study). Cephalalgia [Internet]. SAGE Publications; 2018 Mar 4;38(6):1038–48. Available from: https://doi.org/10.1177/0333102418762525
Podoll K, Robinson D, Sacks O. Migraine art: the migraine experience from within. Berkeley, (CA): North Atlantic Books; 2009.
Mack KJ, Patterson MC, Dashe JF. Preventive treatment of migraine in children. UpToDate (en línea)(consultado el 29/03/2016).
Lewis D, Ashwal S, Hershey A, Hirtz D, Yonker M, Silberstein S. Practice Parameter: Pharmacological treatment of migraine headache in children and adolescents: Report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2004 Dec 28;63(12):2215–24. Available from: https://doi.org/10.1212/01.wnl.0000147332.41993.90
El-Chammas K, Keyes J, Thompson N, Vijayakumar J, Becher D, Jackson JL. Pharmacologic Treatment of Pediatric Headaches. JAMA Pediatrics [Internet]. American Medical Association (AMA); 2013 Mar 1;167(3):250. Available from: https://doi.org/10.1001/jamapediatrics.2013.508
MINISTRY OF HEALTH HEALTH UKRAINIAN, Department of Pharmaceutical Affairs, State Expert Center of the Ministry of Health and Health of Ukraine, “State Register of State Units”. Available from: http://www.drlz.com.ua/
Anti-CGRP Monoclonal Antibodies for Migraine Prevention [Internet]. Medscape. 2018. Available from: https://www.medscape.com/viewarticle/905882
How to Cite
This work is licensed under a Creative Commons Attribution 4.0 International License