COVID-19 and headache


  • A V Honchar Universal Clinic “Oberig”, Kyiv
  • P V Kovalchuk Medical Center “Evidence – Modern Pediatrics”, Vinnytsia
  • O V Katilov National Pirogov Memorial Medical University, Vinnytsia



headache, COVID-19, headache attributed to viral illness, differential diagnosis, neurology


Since the start of the COVID-19 pandemic scientists from all over the world have been working thoroughly to study this disease and its connections with other pathological conditions. In this review the specificity of headache in patients who had had COVID-19 infection in terms of differential diagnosis is estimated. Due to increasing amount of cases, this information will be extremely helpful for doctors who are managing such patient as well as for headache specialists.


Download data is not yet available.


Peng K-P. Association between COVID-19 and headache: What evidence and history tell us. Cephalalgia [Internet]. SAGE Publications; 2020 Nov;40(13):1403–5. Available from:

Tu TM, Goh C, Tan YK, Leow AS, Pang YZ, Chien J, et al. Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review. Journal of Stroke and Cerebrovascular Diseases [Internet]. Elsevier BV; 2020 Dec;29(12):105379. Available from:

Mantero V, Basilico P, Costantino G, Pozzetti U, Rigamonti A, Salmaggi A. Recurrent Transient Ischemic Attack in a Young Patient with COVID-19. Journal of Clinical Neurology [Internet]. Korean Neurological Association; 2020;16(3):513. Available from:

Divani AA, Andalib S, Di Napoli M, Lattanzi S, Hussain MS, Biller J, et al. Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights. Journal of Stroke and Cerebrovascular Diseases [Internet]. Elsevier BV; 2020 Aug;29(8):104941. Available from:

Toscano G, Palmerini F, Ravaglia S, Ruiz L, Invernizzi P, Cuzzoni MG, et al. Guillain–Barré Syndrome Associated with SARS-CoV-2. New England Journal of Medicine [Internet]. Massachusetts Medical Society; 2020 Jun 25;382(26):2574–6. Available from:

Gutiérrez-Ortiz C, Méndez-Guerrero A, Rodrigo-Rey S, San Pedro-Murillo E, Bermejo-Guerrero L, Gordo-Mañas R, et al. Miller Fisher syndrome and polyneuritis cranialis in COVID-19. Neurology [Internet]. Ovid Technologies (Wolters Kluwer Health); 2020 Apr 17;95(5):e601–e605. Available from:

Souhel Najjar et al., Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports J Neuroinflammation. 2020; 17: 231.

Najjar S, Najjar A, Chong DJ, Pramanik BK, Kirsch C, Kuzniecky RI, et al. Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports. Journal of Neuroinflammation [Internet]. Springer Science and Business Media LLC; 2020 Aug 6;17(1). Available from:

Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B. COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features. Radiology [Internet]. Radiological Society of North America (RSNA); 2020 Aug;296(2):E119–E120. Available from:

Caronna E, Ballvé A, Llauradó A, Gallardo VJ, Ariton DM, Lallana S, et al. Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution. Cephalalgia [Internet]. SAGE Publications; 2020 Nov;40(13):1410–21. Available from:

Trigo López J, García-Azorín D, Planchuelo-Gómez Á, García-Iglesias C, Dueñas-Gutiérrez C, Guerrero ÁL. Phenotypic characterization of acute headache attributed to SARS-CoV-2: An ICHD-3 validation study on 106 hospitalized patients. Cephalalgia [Internet]. SAGE Publications; 2020 Nov;40(13):1432–42. Available from:

Sampaio Rocha-Filho PA, Magalhães JE. Headache associated with COVID-19: Frequency, characteristics and association with anosmia and ageusia. Cephalalgia [Internet]. SAGE Publications; 2020 Nov;40(13):1443–51. Available from:

Trigo J, García-Azorín D, Planchuelo-Gómez Á, Martínez-Pías E, Talavera B, Hernández-Pérez I, et al. Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study. The Journal of Headache and Pain [Internet]. Springer Science and Business Media LLC; 2020 Jul 29;21(1). Available from:

Politi LS, Salsano E, Grimaldi M. Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia. JAMA Neurology [Internet]. American Medical Association (AMA); 2020 Aug 1;77(8):1028. Available from:

Bonfert M, Ebinger F, Blankenburg M, Ertl-Wagner B, Heinen F, Roser T. Primary versus Secondary Headache in Children: A Frequent Diagnostic Challenge in Clinical Routine. Neuropediatrics [Internet]. Georg Thieme Verlag KG; 2013 Jan 3;44(01):034–9. Available from:

Back to school: the real symptoms to look out for in children, September 7, 2020, accessed online 29.11.2020

Mayor S. Covid-19: UK studies find gastrointestinal symptoms are common in children. BMJ [Internet]. BMJ; 2020 Sep 7;m3484. Available from:

Cui X, Zhang T, Zheng J, Zhang J, Si P, Xu Y, et al. Children with coronavirus disease 2019: A review of demographic, clinical, laboratory, and imaging features in pediatric patients. Journal of Medical Virology [Internet]. Wiley; 2020 Jun 2;92(9):1501–10. Available from:

Ciuca IM. COVID-19 in Children: An Ample Review. Risk Management and Healthcare Policy [Internet]. Informa UK Limited; 2020 Jun;Volume 13:661–9. Available from:

Peng K-P. Association between COVID-19 and headache: What evidence and history tell us. Cephalalgia [Internet]. SAGE Publications; 2020 Nov;40(13):1403–5. Available from:

Rozen TD. Daily persistent headache after a viral illness during a worldwide pandemic may not be a new occurrence: Lessons from the 1890 Russian/Asiatic flu. Cephalalgia [Internet]. SAGE Publications; 2020 Nov;40(13):1406–9. Available from:

Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia [Internet]. SAGE Publications; 2018 Jan;38(1):1–211. Available from:

Marchioni E, Tavazzi E, Bono G, Minoli L, Bastianello S, Sinforiani E, et al. Headache Attributed to Infection: Observations on the IHS Classification (ICHD-II). Cephalalgia [Internet]. SAGE Publications; 2006 Dec;26(12):1427–33. Available from:

Ragab D, Salah Eldin H, Taeimah M, Khattab R, Salem R. The COVID-19 Cytokine Storm; What We Know So Far. Frontiers in Immunology [Internet]. Frontiers Media SA; 2020 Jun 16;11. Available from:

Marinis MD, Welch K. Headache Associated with Non-Cephalic Infections: Classification and Mechanisms. Cephalalgia [Internet]. SAGE Publications; 1992 Aug;12(4):197–201. Available from:

Magdy R, Hussein M, Ragaie C, Abdel-Hamid HM, Khallaf A, Rizk HI, et al. Characteristics of headache attributed to COVID-19 infection and predictors of its frequency and intensity: A cross sectional study. Cephalalgia [Internet]. SAGE Publications; 2020 Nov;40(13):1422–31. Available from:

Kovalchuk PV, Katilov OV, Panenko SO. Modern approaches to diagnostics and treatment of migraine in children. Pain medicine [Internet]. Interdisciplinar Academy of Pain Medicine; 2019 Feb 21;3(4):41–53. Available from:

Журнал Pain Medicine 2020 року



How to Cite

Honchar AV, Kovalchuk PV, Katilov OV. COVID-19 and headache. PMJUA [Internet]. 2021 Mar. 11 [cited 2023 Feb. 8];5(4):4-7. Available from:



Problem article

Most read articles by the same author(s)